Layer I as a putative neurogenic niche in young adult guinea pig cerebrum.
Layer I as a putative neurogenic niche in young adult guinea pig cerebrum.
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第一层作为年轻成年豚鼠大脑中假定的神经源性生态位
DOI：
10.1016/j.mcn.2010.06.009
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Yan XX
中科院分区：
文献类型：
--
作者：
Xiong K;Cai Y;Zhang XM;Huang JF;Liu ZY;Fu GM;Feng JC;Clough RW;Patrylo PR;Luo XG;Hu CH;Yan XX
大量表达典型的未成熟神经元标记物（包括双皮质素（DCX+））的细胞存在于年轻和成年豚鼠和其他大型哺乳动物大脑皮层的第二层周围，其起源和生物学意义有待进一步表征。我们在这里显示，在年轻的成年豚鼠，这些DCX+细胞是伴随着在原位细胞分裂周围的表层皮质层主要是在第一层，但他们共同表达增殖细胞核抗原和早期神经元的命运决定因子，PAX 6。在给予这种有丝分裂指示剂后，少量这些DCX+细胞也与BrdU共定位。颅脑X射线照射导致DCX+细胞周围的第二层下降，和新的环境探索诱导c-Fos表达这些细胞在几个新皮质区。总之，这些数据是兼容的概念，DCX+皮层神经元周围的第二层可能来自增殖的神经元前体周围的层I在年轻的成年豚鼠大脑，这些细胞可能是由生理条件下的经验调制。
A considerable number of cells expressing typical immature neuronal markers including doublecortin (DCX+) are present around layer II in the cerebral cortex of young and adult guinea pigs and other larger mammals, and their origin and biological implication await further characterization. We show here in young adult guinea pigs that these DCX+ cells are accompanied by in situ cell division around the superficial cortical layers mostly in layer I, but they co-express proliferating cell nuclear antigen and an early neuronal-fate determining factor, PAX6. A small number of these DCX+ cells also colocalize with BrdU following administration of this mitotic indicator. Cranial X-ray irradiation causes a decline of DCX+ cells around layer II, and novel environmental exploration induces c-Fos expression among these cells in several neocortical areas. Together, these data are compatible with a notion that DCX+ cortical neurons around layer II might derive from proliferable neuronal precursors around layer I in young adult guinea pig cerebrum, and that these cells might be modulated by experience under physiological conditions.
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影响因子：
25
作者：
Bystron, Irina;Rakic, Pasko;Blakemore, Colin
通讯作者：
Blakemore, Colin
影响因子：
5.3
作者：
Cai, Yan;Xiong, Kun;Chu, Yaping;Luo, Duan-Wu;Luo, Xue-Gang;Yuan, Xian-Yui;Struble, Robert G.;Clough, Richard W.;Spencer, Dennis D.;Williamson, Anne;Kordower, Jeffrey H.;Patrylo, Peter R.;Yan, Xiao-Xin
通讯作者：
Yan, Xiao-Xin
影响因子：
3.3
作者：
BONFANTI, L;OLIVE, S;THEODOSIS, DT
通讯作者：
THEODOSIS, DT
影响因子：
5.3
作者：
Costa, Marcos R.;Kessaris, Nicoletta;Hedin-Pereira, Cecilia
通讯作者：
Hedin-Pereira, Cecilia
影响因子：
64.8
作者：
Letinic, K;Zoncu, R;Rakic, P
通讯作者：
Rakic, P