Toxic Effect of Mycotoxins on Cardiovascular System: A Topic Worthy of Further Study
Toxic Effect of Mycotoxins on Cardiovascular System: A Topic Worthy of Further Study
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霉菌毒素对心血管系统的毒性作用：值得进一步研究的课题
DOI：
10.1080/87559129.2021.1950172
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发表时间：
2021-07
影响因子：
5.8
通讯作者：
Dianjun Su
中科院分区：
文献类型：
--
作者：
Kewei Wang;Shoujun Liu;Xufeng Zhang;Dianjun Su
流行病学和实验研究已证实霉菌毒素引起的心肌损伤。柠檬绿素（CIT）是一种来自黄绿色青霉的毒素，容易在潮湿和寒冷的环境中生长。摄入CIT污染的食物可引起心肌损伤，这可能是地方性克山病的病因。黄霉米可以产生有毒的CIT并诱发脚气病相关的心功能不全。鉴于克山病与心源性脚气病（湿性脚气病）的相似性，认为这两种疾病可能是同病异名。近年来的研究数据表明，CIT和其他霉菌毒素也可能与血管内皮损伤和动脉粥样硬化的发病有关。霉菌毒素可引发心肌细胞氧化应激、自由基产生和能量代谢异常，从而通过坏死和凋亡机制导致细胞死亡。心肌中的线粒体途径在霉菌毒素引起的细胞毒性中发挥着关键作用。重要的是，霉菌毒素引起血管内皮细胞损伤，这是动脉粥样硬化发病机制的直接危险因素。显然，阐述霉菌毒素在心血管疾病发病机制中的作用是一个新课题。在今后的学习中还有很多问题需要解答。
Mycotoxin-caused myocardial injury has been demonstrated based on epidemiological and experimental studies. Citreoviridin (CIT) is a toxin from yellow-green Penicillium easily grown in wet and cold environment. The CIT-contaminated food intake could cause myocardial injury, which might be the etiology of endemic Keshan disease. The yellow mildewed rice could produce toxic CIT and induced beriberi-linked cardiac insufficiency. In view of the similarity between Keshan disease and cardiac beriberi (wet beriberi), it was considered that the two diseases might be the same illness with different names. Research data in recent years demonstrated that the CIT and other mycotoxins might be also associated with the vascular endothelial damage and the pathogenesis of atherosclerosis. The mycotoxin could trigger oxidative stress, free radical production, and abnormal energy metabolism in cardiomyocytes, which resulted in cell death through necrotic and apoptotic mechanisms. The mitochondrial pathway in myocardium played a critical role in mycotoxin-caused cytotoxicity. Importantly, the mycotoxins caused cell damage in vascular endothelium, which was a direct risk factor in the pathogenesis of atherosclerosis. Obviously, it is a new topic to elaborate the role of mycotoxins in the pathogenic mechanism of cardiovascular disease. There are a lot of questions needs to be answered in future study.
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DOI：
10.1080/02652038809373711
发表时间：
1988-07
期刊：
Food additives and contaminants
影响因子：
--
作者：
H. V. van Egmond;W. E. Paulsch;E. Sizoo
通讯作者：
H. V. van Egmond;W. E. Paulsch;E. Sizoo
DOI：
10.1265/jjh.56.641
发表时间：
2002-01
期刊：
Nihon eiseigaku zasshi. Japanese journal of hygiene
影响因子：
--
作者：
Yunbao Liu;M. Chiba;Y. Inaba;M. Kondo
通讯作者：
Yunbao Liu;M. Chiba;Y. Inaba;M. Kondo
影响因子：
3.5
作者：
Li, Qi;Liu, Mingfa;Wang, Tong
通讯作者：
Wang, Tong
影响因子：
17.3
作者：
Y. Sugiyama;Akihiro Seita
通讯作者：
Y. Sugiyama;Akihiro Seita
DOI：
--
发表时间：
2013-05
期刊：
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
影响因子：
--
作者：
Yu-xiao Sun;Yanyan Zhu;Jianhong Zhu;Xiao‐lin Niu;Chao Yan;Guang Yang;Lin Lin-Lin
通讯作者：
Yu-xiao Sun;Yanyan Zhu;Jianhong Zhu;Xiao‐lin Niu;Chao Yan;Guang Yang;Lin Lin-Lin