Association of infant diet with subsequent obesity at 2-5 years among children exposed to gestational diabetes: the SWIFT study.
Association of infant diet with subsequent obesity at 2-5 years among children exposed to gestational diabetes: the SWIFT study.
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DOI：
10.1007/s00125-020-05379-y
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发表时间：
2021-05
期刊：
影响因子：
8.2
通讯作者：
Gunderson EP
中科院分区：
文献类型：
--
作者：
Vandyousefi S;Davis JN;Gunderson EP
这项纵向分析评估了患有妊娠糖尿病 (GDM) 的幼儿中，任何母乳喂养 (BF) 或纯母乳喂养 (EBF) 以及从出生到 1 岁期间摄入含糖饮料 (SSB) 和 100% 果汁与随后超重和肥胖的独立关联和联合关联。该分析利用了 GDM 后妇女、婴儿喂养和 2 型糖尿病研究 (SWIFT) 参与者前瞻性收集的数据； 1,035 名孕妇（20-45 岁）被诊断患有 GDM，其中 75% 是黑人、西班牙裔或亚洲人种和族裔。通过现场检查、电话访谈和每月邮寄调查（从出生到一岁）的研究方案评估母婴二元特征和婴儿饮食摄入量。从出生时（2008-2011 年）和 2-5 岁（2010-2016 年）的电子健康记录中获取儿童体重、身长和身高，以对 BMI 百分位组进行分类（n=835）。充足的 BF（≥6 个月）、足够的 EBF 持续时间（≥6 个月）以及第一年的 SSB 和 100% 果汁摄入量与 2-5 岁儿童肥胖独立相关（均 p<0.05）。与 EBF 充足且未摄入 SSB 或 100% 果汁的儿童相比，EBF 充足且摄入 100% 果汁和/或 SSB 的儿童肥胖的几率高出四到五倍（对于 100% 果汁，aOR 4.2，95% CI：1.6，11.2；对于果汁或果汁，aOR 4.5，95% CI：1.4，8.5） SSB；和 SSB 的 aOR 4.7，95% CI：1.4，15；所有 p<0.01），而 EBF 不足（<6 个月）和摄入 100% 果汁和/或 SSB 的人肥胖的几率高出 6 至 12 倍（果汁的 aOR 6.4，95% CI：2.4，17.2；aOR 6.6，果汁或 SSB 的 95% CI：2.7，14.8；SSB 的 aOR 12.2，95% CI：4.3，25；所有 p<0.001）。与BF充足且未摄入SSB或100%果汁的儿童相比，BF充足且摄入100%果汁和/或SSB的儿童肥胖的几率高出三倍（果汁aOR 3.1, 95% CI:1.1, 7.3；果汁或SSB aOR 3.3, 95% CI:1.3, 8.3；aOR 3.4， SSB 的 95% CI：1.3，8.5；所有 p<0.05），而 BF 不足（<6 个月）和摄入 100% 果汁和/或 SSB 的人肥胖的几率高出五到十倍（果汁的 aOR 4.8，95% CI：2.3，12.2；水果的 aOR 6.0，95% CI：2.5，12.8）果汁或 SSB；对于 SSB，aOR 9.5，95% CI：3.7，15.1；这是第一项前瞻性评估 BF 或 EBF 持续时间以及生命第一年 SSB 和 100% 果汁摄入量与暴露于 GDM 的儿童随后肥胖之间关系的研究。充足的 BF 或 EBF 加上婴儿早期避免 SSB 和 100% 果汁可能会改善这一高危人群未来的儿童肥胖。
This longitudinal analysis evaluated the independent and joint associations of any breastfeeding (BF) or exclusive BF (EBF) and intake of sugar-sweetened beverages (SSBs) and 100% fruit juice from birth to 1 year with subsequent overweight and obesity among young children exposed to gestational diabetes (GDM). The analysis utilised prospectively collected data from participants enrolled in the Study of Women, Infant Feeding and Type 2 Diabetes after GDM (SWIFT); 1,035 pregnant women (20–45 years) diagnosed with GDM, of whom 75% were of Black, Hispanic or Asian race and ethnicity. Mother-infant dyad characteristics and infant dietary intake were assessed via research protocols at in-person examinations, telephone interviews and monthly mailed surveys from birth to 1 year. Child weight, length and height were obtained from electronic health records at birth (2008-2011) and ages 2–5 years (2010-2016) to classify BMI percentile groups (n=835). Adequate BF (≥6 months), adequate EBF duration (≥6 months), and SSB and 100% fruit juice intake in the first year were independently associated with child obesity at ages 2–5 years (all p<0.05). Compared with children with adequate EBF and no intake of SSB or 100% fruit juice, those with adequate EBF and intake of 100% fruit juice and/or SSBs had a four- to fivefold higher odds of obesity (aOR 4.2, 95% CI: 1.6, 11.2 for 100% fruit juice; aOR 4.5, 95% CI: 1.4, 8.5 for fruit juice or SSBs; and aOR 4.7, 95% CI:1.4, 15 for SSBs; all p<0.01), while those with inadequate EBF (<6 months) and intake of 100% fruit juice and/or SSBs had a six- to 12-fold higher odds of obesity (aOR 6.4, 95% CI:2.4, 17.2 for fruit juice; aOR 6.6, 95% CI:2.7, 14.8 for fruit juice or SSBs; and aOR 12.2, 95% CI:4.3, 25 for SSBs; all p<0.001). Compared with children with adequate BF and no intake of SSB or 100% fruit juice, those with adequate BF and intake of 100% fruit juice and/or SSBs had a threefold higher odds of obesity (aOR 3.1, 95% CI:1.1, 7.3 for fruit juice; aOR 3.3, 95% CI:1.3, 8.3 for fruit juice or SSBs; and aOR 3.4, 95% CI:1.3, 8.5 for SSBs; all p<0.05), while those with inadequate BF (<6 months) and intake of 100% fruit juice and/or SSB were associated with five- to tenfold higher odds of obesity (aOR 4.8, 95% CI:2.3, 12.2 for fruit juice; aOR 6.0, 95% CI:2.5, 12.8 for fruit juice or SSBs; aOR 9.5, 95% CI:3.7, 15.1 for SSBs; all p<0.05). This is the first study to prospectively evaluate the relation of BF or EBF duration and intake of SSB and 100% fruit juice during the first year of life with subsequent obesity in children exposed to GDM. Adequate BF or EBF combined with avoidance of SSB and 100% fruit juice during early infancy may ameliorate future child obesity in this high-risk population.
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影响因子：
3.8
作者：
Gunderson EP;Greenspan LC;Faith MS;Hurston SR;Quesenberry CP Jr;SWIFT Offspring Study Investigators
通讯作者：
SWIFT Offspring Study Investigators
影响因子：
3.1
作者：
Gunderson EP;Hurston SR;Dewey KG;Faith MS;Charvat-Aguilar N;Khoury VC;Nguyen VT;Quesenberry CP Jr
通讯作者：
Quesenberry CP Jr
影响因子：
3.8
作者：
Bider-Canfield, Z.;Martinez, M. P.;Xiang, A. H.
通讯作者：
Xiang, A. H.
影响因子：
3.8
作者：
Cantoral, A.;Tellez-Rojo, M. M.;Peterson, K.
通讯作者：
Peterson, K.
影响因子：
6.9
作者：
Lim, Sungwoo;Zoellner, Jamie M.;Lepkowski, James M.
通讯作者：
Lepkowski, James M.