Cognitive and neuroimaging correlates of financial exploitation vulnerability in older adults without dementia: Implications for early detection of Alzheimer's disease.
Cognitive and neuroimaging correlates of financial exploitation vulnerability in older adults without dementia: Implications for early detection of Alzheimer's disease.
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DOI：
10.1016/j.neubiorev.2022.104773
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发表时间：
2022-09
影响因子：
8.2
通讯作者：
Han, S. Duke
中科院分区：
文献类型：
--
作者：
Fenton, Laura;Weissberger, Gali H.;Boyle, Patricia A.;Mosqueda, Laura;Yassine, Hussein N.;Nguyen, Annie L.;Lim, Aaron C.;Han, S. Duke
阿尔茨海默病(AD)的神经病理学特征在标准神经心理测试临床可检测到认知变化之前就开始积累数年至数十年。这对早期干预工作提出了挑战，并促进了识别早期神经病理变化的行为相关性的研究。最近的证据表明，决策受损导致的金融剥削脆弱性(FEV)可能是AD神经病理的早期行为表现，从而表明随后认知能力下降的可能性增加。因此，有必要了解FEV的基本机制，以确定因AD而有认知能力下降风险的个人，并赋予和保护易受经济剥削的老年人的权力和保护。在目前的审查中，我们首先强调对老年人的经济剥削的破坏性后果。然后，我们总结了非痴呆老年人FEV的认知、神经影像和神经病理相关性的研究，并提出了AD病理的早期积累表现为FEV的理论模型。最后，我们总结了临床意义和未来研究的方向。
Neuropathology characteristic of Alzheimer’s disease (AD) begins to accumulate years to decades before cognitive changes are clinically detectable on standard neuropsychological tests. This presents a challenge for early intervention efforts and has spurred research on the identification of behavioral correlates of early neuropathological changes. Recent evidence suggests that financial exploitation vulnerability (FEV) due to impaired decision making may serve as an early behavioral manifestation of AD neuropathology, thereby indicating an increased likelihood for subsequent cognitive decline. An understanding of the underlying mechanisms of FEV is therefore warranted for the identification of individuals at risk for cognitive decline due to AD, and for empowering and protecting older adults vulnerable to financial exploitation. In the current review, we first highlight the devastating consequences of financial exploitation of older adults. We then summarize research on the cognitive, neuroimaging, and neuropathological correlates of FEV in older adults without dementia and propose a theoretical model in which early accumulation of AD pathology manifests as FEV. We conclude with clinical implications and directions for future research.
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影响因子：
2.7
作者：
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