Repeated binge ethanol administration during adolescence enhances voluntary sweetened ethanol intake in young adulthood in male and female rats.
Repeated binge ethanol administration during adolescence enhances voluntary sweetened ethanol intake in young adulthood in male and female rats.
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DOI：
10.1016/j.pbb.2010.07.008
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Kirstein CL
中科院分区：
文献类型：
--
作者：
Maldonado-Devincci AM;Alipour KK;Michael LA;Kirstein CL
在美国，酗酒是一个越来越令人担忧的问题，特别是在青少年中。在这一发育阶段，酒精的使用通常会开始，并已被证明会对大脑结构和功能以及大鼠的认知/行为障碍造成有害影响。在狂欢模型中，动物通常在三到四天的时间内反复服用高剂量的乙醇，导致这些影响。很少有工作进行了旨在调查长期的行为后果，反复狂欢管理在青春期后乙醇诱导的行为在青年和成年。重复的四天狂饮模型可以作为人类青少年饮酒模式的一个很好的近似，因为这类似于人类酗酒者的“bender”。本实验研究了在青春期对甜乙醇（实验1）或糖精（实验2）的摄入量在青年期重复放纵乙醇管理诱导的剂量反应和性别相关的差异。在两项实验中，在出生后第28-31天（PND）、PND 35-38天和PND 42-45天，向青春期大鼠灌胃给予乙醇（1.5、3.0或5.0 g/kg）或水。大鼠从PND 46-59开始禁欲。随后，在年轻的成年人，乙醇和糖精的摄入量进行了评估。在青春期接触任何剂量的乙醇都能显著增加成年后的乙醇摄入量。然而，虽然雌性大鼠的总体g/kg摄入量较高，但雄性大鼠似乎更容易受到青少年乙醇暴露对随后成年后乙醇摄入量增加的影响。在青春期暴露于乙醇并没有改变雄性或雌性大鼠在成年初期的糖精摄入量。考虑到青春期是乙醇实验和消费通常开始的发育期，目前的一组实验表明阐明早期暴饮暴食模式乙醇暴露对随后的饮酒倾向的影响的重要性。
Binge alcohol consumption is a rising concern in the United States, especially among adolescents. During this developmental period alcohol use is usually initiated and has been shown to cause detrimental effects on brain structure and function as well as cognitive/behavioral impairments in rats. Binge models, where animals are repeatedly administered high doses of ethanol typically over a period of three or four days cause these effects. There has been little work conducted aimed at investigating the long-term behavioral consequences of repeated binge administration during adolescence on later ethanol-induced behavior in young adulthood and adulthood. The repeated four-day binge model may serve as a good approximate for patterns of human adolescent alcohol consumption as this is similar to a “bender” in human alcoholics. The present set of experiments examined the dose-response and sex-related differences induced by repeated binge ethanol administration during adolescence on sweetened ethanol (Experiment 1) or saccharin (Experiment 2) intake in young adulthood. In both experiments, on postnatal days (PND) 28–31, PND 35–38 and PND 42–45, ethanol (1.5, 3.0 or 5.0 g/kg) or water was administered intragastrically to adolescent rats. Rats underwent abstinence from PND 46–59. Subsequently, in young adulthood, ethanol and saccharin intake were assessed. Exposure to any dose of ethanol during adolescence significantly enhanced ethanol intake in adulthood. However, while female rats had higher overall g/kg intake, males appear to be more vulnerable to the impact of adolescent ethanol exposure on subsequently increased ethanol intake in young adulthood. Exposure to ethanol during adolescence did not alter saccharin consumption in young adulthood in male or female rats. Considering that adolescence is the developmental period in which ethanol experimentation and consumption is usually initiated, the present set of experiments demonstrate the importance of elucidating the impact of early binge-pattern ethanol exposure on the subsequent predisposition to drink later in life.
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影响因子：
2.3
作者：
FILES, FJ;LEWIS, RS;SAMSON, HH
通讯作者：
SAMSON, HH
影响因子：
2.3
作者：
Hargreaves, Garth A.;Monds, Lauren;McGregor, Iain S.
通讯作者：
McGregor, Iain S.
影响因子：
3.6
作者：
Fuellgrabe, Marc W.;Vengeliene, Valentina;Spanagel, Rainer
通讯作者：
Spanagel, Rainer
DOI：
10.1111/j.1530-0277.2002.tb02585.x
发表时间：
2002-05-01
影响因子：
3.2
作者：
Ford, MM;Eldridge, JC;Samson, HH
通讯作者：
Samson, HH
DOI：
10.1111/j.1530-0277.2000.tb02071.x
发表时间：
2000-06-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Hill, KG;White, HR;Catalano, RF
通讯作者：
Catalano, RF