Impact of probiotics on the immune response to influenza vaccination is strongly influenced by ageing
Impact of probiotics on the immune response to influenza vaccination is strongly influenced by ageing
复制标题
益生菌对流感疫苗免疫反应的影响受到衰老的强烈影响
DOI：
10.1111/nbu.12253
复制
发表时间：
2017
影响因子：
3.3
通讯作者：
Yaqoob P
中科院分区：
文献类型：
--
作者：
Yaqoob P
65岁以上人群的流感疫苗接种成功率较低，因为与年龄相关的免疫力下降。因此，迫切需要改进疫苗接种反应的战略。新出现的证据表明，肠道微生物群的改变可能潜在地影响抗病毒防御并调节病毒感染的结果。作为生物技术和生物科学研究委员会（BBSRC）饮食和健康研究产业俱乐部（DRINC）资助项目的一部分，研究确定了一种新型益生菌（B. longum婴儿sccug 52486）的免疫调节特性，并证明对这种益生菌和其他益生菌的免疫反应高度依赖于供体的年龄。老年受试者对流感疫苗接种的反应明显低于年轻受试者，尽管益生菌前和益生菌组合（合成菌）并没有改善应答，但益生菌在年轻和老年受试者中有不同效果的趋势。然而，进一步的调查显示，与那些随机分到安慰剂组的人相比，服用合成疫苗的老年受试者在可能对疫苗产生反应的能力方面已经处于明显的劣势，因为在基线时，随机分组之间的免疫衰老存在差异。这可能影响了干预的结果，这一观察结果的含义是深远的，因为它表明，未能完全理解受试者表型可能导致对数据的错误解释。因此，这项工作为基线受试者特征（特别是免疫表型）对干预结果的影响提供了有价值的见解，并强调了对受试者前瞻性随机化更详细的免疫标记物的需求。
Influenza vaccination in the over 65s suffers from low success rates because of the age‐associated decline in immunity. Strategies for improving the response to vaccination are therefore urgently needed. Emerging evidence suggests that alteration of the gut microbiota could potentially influence antiviral defences and modulate the outcome of viral infections. Research conducted as part of a Biotechnology and Biological Sciences Research Council (BBSRC) Diet and Health Research Industry Club (DRINC)‐funded project identified immunoregulatory properties of a novel probiotic (B. longum infantisCCUG 52486) and demonstrated that the immune response to this and other probiotics was highly dependent on the age of the donor. Older subjects had a markedly poorer response to influenza vaccination than young subjects and, although a pre‐ and probiotic combination (synbiotic) did not improve the response, there were trends for differential effects of the probiotic in young and older subjects. However, further interrogation revealed that the older subjects on the synbiotic were already at a significant disadvantage in terms of likely ability to respond to the vaccine compared with those randomised to the placebo because of differences in immunosenescence between the randomised groups at baseline. This may have influenced the outcome of the intervention and the implications of this observation are far reaching as it suggests that failure to fully understand subject phenotype could lead to incorrect interpretation of data. The work therefore provides valuable insight into the influence of baseline subject characteristics – particularly immune phenotype – on the outcome of the intervention and highlights the need for more detailed immunological markers for prospective randomisation of subjects.
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国际免疫营养研讨会第八场：益生菌在机体防御和代谢平衡中的作用益生菌与疫苗的免疫反应
DOI：
--
发表时间：
2010
期刊：
影响因子：
--
作者：
T. Macdonald;Iona Bell
通讯作者：
Iona Bell
影响因子：
5.3
作者：
Gardner, EM;Bernstein, ED;Murasko, DM
通讯作者：
Murasko, DM
影响因子：
12.2
作者：
Shida, Kan;Nanno, Masanobu;Nagata, Satoru
通讯作者：
Nagata, Satoru
从健康老年人粪便中分离的推定益生菌的分子鉴定和抗病原活性
DOI：
--
发表时间：
2004
期刊：
影响因子：
--
作者：
E. Likotrafiti;K. Manderson;F. Fava;K. Tuohy;G. Gibson;R. Rastall
通讯作者：
R. Rastall
维生素 E、维生素 A 和锌状态与老年人对流感疫苗的血清学反应无关：一项观察性前瞻性队列研究。
DOI：
10.1016/j.nutres.2013.12.004
发表时间：
2014
期刊：
Nutrition research (New York, N.Y.)
影响因子：
--
作者：
Sundaram,MariaE;Meydani,SiminNikbin;Vandermause,Mary;Shay,DavidK;Coleman,LauraA
通讯作者：
Coleman,LauraA