Meta-analysis of lymphocytes in schizophrenia: clinical status and antipsychotic effects.
Meta-analysis of lymphocytes in schizophrenia: clinical status and antipsychotic effects.
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DOI：
10.1016/j.biopsych.2012.09.007
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发表时间：
2013-05-15
影响因子：
10.6
通讯作者：
Mellor, Andrew
中科院分区：
文献类型：
--
作者：
Miller, Brian J.;Gassama, Bintou;Sebastian, Dale;Buckley, Peter;Mellor, Andrew
精神分裂症与免疫系统功能障碍有关，包括血液免疫细胞参数异常。我们对这些关联进行了荟萃分析，考虑了临床状态和精神病急性加重后抗精神病治疗的影响。我们通过检索Pub Med、PsychInfo和ISI以及已确定研究的参考文献列表来确定文章。16项血液淋巴细胞研究符合纳入标准。单核吞噬系统的meta分析数据不足。在横断面研究中，急性复发住院患者（AR）的CD4%和CD56%显著增加。药物源性首发精神病（FEP）患者总淋巴细胞、CD3、CD4绝对水平及CD4/CD8比值显著升高，CD3%显著降低。在纵向研究中，CD4/CD8比值似乎是状态相关的标记，因为它在精神病急性加重的抗精神病药物治疗后下降。绝对CD56水平似乎是一个特征标记，因为抗精神病药物治疗复发后CD56水平显著升高。drug-naïve FEP的血淋巴细胞异常提示其作用可能独立于抗精神病药物。虽然一些参数（CD4/CD8）可能是精神病急性加重的状态标记，但其他参数（CD56）可能是特征标记，但需要更多的纵向研究。虽然这些发现可以为未来的假设检验提供基础，但相对较少的研究和受试者，缺乏与临床特征相关的数据，以及对潜在混杂因素的考虑不足，限制了结果。
Schizophrenia is associated with immune system dysfunction, including abnormal blood immune cell parameters. We performed a meta-analysis of these associations, considering the effect of clinical status and antipsychotic treatment following an acute exacerbation of psychosis. We identified articles by searching Pub Med, PsychInfo, and ISI, and the reference lists of identified studies. Sixteen studies of blood lymphocytes met the inclusion criteria. There was insufficient data for a meta-analysis of the mononuclear phagocytic system. In cross-sectional studies, there was a significant increase in the CD4% and CD56% in acutely relapsed inpatients (AR). Absolute levels of total lymphocytes, CD3, and CD4, and the CD4/CD8 ratio were significantly increased, and the CD3% was significantly decreased in drug-native first-episode psychosis (FEP). In longitudinal studies, the CD4/CD8 ratio appeared to be state-related markers, as it decreased following antipsychotic treatment for acute exacerbations of psychosis. Absolute CD56 levels appeared to be a trait marker, as levels significantly increased following antipsychotic treatment for relapse. Blood lymphocyte abnormalities in drug-naïve FEP suggest an effect that may be independent of antipsychotic medications. While some parameters (CD4/CD8) may be state markers for acute exacerbations of psychosis, others (CD56) may be trait markers, however more longitudinal studies are needed. Although these findings could provide the basis for future hypothesis testing, a relatively small number of studies and subjects, lack of correlative data with clinical features, and inadequate consideration of potential confounding factors limit the results.
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影响因子：
10.6
作者：
ACHIRON, A;NOY, S;LAOR, N
通讯作者：
LAOR, N
影响因子：
4.5
作者：
HORNBERG, M;AROLT, V;KIRCHNER, H
通讯作者：
KIRCHNER, H
影响因子：
11.3
作者：
Arolt, V;Weitzsch, C;Kirchner, H
通讯作者：
Kirchner, H
DOI：
10.1111/j.1749-6632.1987.tb35829.x
发表时间：
1987-05-28
影响因子：
5.2
作者：
GANGULI, R;RABIN, BS;RAGU, U
通讯作者：
RAGU, U
影响因子：
2.2
作者：
Hunter, JE;Schmidt, FL
通讯作者：
Schmidt, FL