Domain-general signals in the cingulo-opercular network for visuospatial attention and episodic memory.
Domain-general signals in the cingulo-opercular network for visuospatial attention and episodic memory.
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DOI：
10.1162/jocn_a_00504
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发表时间：
2014-03
影响因子：
3.2
通讯作者：
Shulman GL
中科院分区：
文献类型：
--
作者：
Sestieri C;Corbetta M;Spadone S;Romani GL;Shulman GL
我们研究了先前描述的与认知控制有关的扣带-穹隆网络(CON)的功能特性。通过对知觉记忆搜索任务和情景记忆搜索任务中常见的fMRI任务诱发活动的分析，确定了该网络的一般性。在参与者在动态变化的环境中或在没有感觉刺激的情况下从情景记忆中寻找行为相关信息的较长时间内，CON(前脑岛/额盖和前扣带/前扣带回/前扣带回皮质)区域显示出持续的信号。CON在两个任务的所有阶段都被激活，涉及试验启动、目标检测、决定和反应，表明它持续参与广泛的认知过程。功能连接性分析表明，在知觉搜索和记忆搜索过程中，CON分别与DAN或DMN区灵活连接。除了CON，只有有限数量的区域，包括外侧前额叶皮质，显示出领域通用的持续活动的证据，尽管在某些情况下，共同的激活可能反映了领域特定区域的功能解剖变异，而不是真正的领域通用。这些额外的区域也显示出与DMN和DAN的任务依赖的功能连接，这表明这一特征不是认知控制的特定标志。最后，多变量聚类分析将CON与之前与认知控制相关的其他额顶区分开，表明了一个独特的指纹。我们的结论是，CON的功能特性和与其他大脑区域的相互作用支持在认知中发挥广泛的作用，这与其作为任务控制网络的特征是一致的。
We investigated the functional properties of a previously described cingulo-opercular network (CON) putatively involved in cognitive control. Analyses of common fMRI task-evoked activity during perceptual and episodic memory search tasks that differently recruited the dorsal attention (DAN) and default mode network (DMN) established the generality of this network. Regions within the CON (anterior insula/frontal operculum and anterior cingulate/presupplementary cortex) displayed sustained signals during extended periods in which participants searched for behaviourally relevant information in a dynamically changing environment or from episodic memory in the absence of sensory stimulation. The CON was activated during all phases of both tasks, which involved trial initiation, target detection, decision and response, indicating its consistent involvement in a broad range of cognitive processes. Functional connectivity analyses showed that the CON flexibly linked with the DAN or DMN regions during perceptual or memory search, respectively. Aside from the CON, only a limited number of regions, including the lateral prefrontal cortex, showed evidence of domain-general, sustained activity, although in some cases the common activations may have reflected the functional-anatomical variability of domain-specific regions rather than a true domain-generality. These additional regions also showed task-dependent functional connectivity with the DMN and DAN, suggesting that this feature is not a specific marker of cognitive control. Finally, multivariate clustering analyses separated the CON from other fronto-parietal regions previously associated with cognitive control, indicating a unique fingerprint. We conclude that the CON’s functional properties and interactions with other brain regions support a broad role in cognition, consistent with its characterization as a task-control network.
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影响因子：
19.9
作者：
Epstein, Russell A.
通讯作者：
Epstein, Russell A.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.8
作者：
Gao, Wei;Lin, Weili
通讯作者：
Lin, Weili
影响因子：
5.7
作者：
Cole, Michael W.;Schneider, Walter
通讯作者：
Schneider, Walter
影响因子：
5.3
作者：
Aron, Adam R.;Behrens, Tim E.;Poldrack, Russell A.
通讯作者：
Poldrack, Russell A.