Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults.
Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults.
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DOI：
10.1016/j.bbr.2013.11.023
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发表时间：
2014-02-01
影响因子：
2.7
通讯作者：
Schon, Karin
中科院分区：
文献类型：
--
作者：
Whiteman, Andrew S.;Young, Daniel E.;He, Xuemei;Chen, Tai C.;Wagenaar, Robert C.;Stern, Chantal E.;Schon, Karin
Convergent evidence from human and non-human animal studies suggests aerobic exercise and increased aerobic capacity may be beneficial for brain health and cognition. It is thought growth factors may mediate this putative relationship, particularly by augmenting plasticity mechanisms in the hippocampus, a brain region critical for learning and memory. Among these factors, glucocorticoids, brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF), hormones that have considerable and diverse physiological importance, are thought to effect normal and exercise-induced hippocampal plasticity. Despite these predictions, relatively few published human studies have tested hypotheses that relate exercise and fitness to the hippocampus, and none have considered the potential links to all of these hormonal components. Here we present cross-sectional data from a study of recognition memory; serum BDNF, cortisol, IGF-1, and VEGF levels; and aerobic capacity in healthy young adults. We measured circulating levels of these hormones together with performance on a recognition memory task, and a standard graded treadmill test of aerobic fitness. Regression analyses demonstrated BDNF and aerobic fitness predict recognition memory in an interactive manner. In addition, IGF-1 was positively associated with aerobic fitness, but not with recognition memory. Our results may suggest an exercise adaptation-related change in the BDNF dose-response curve that relates to hippocampal memory.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
2.9
作者：
Chaddock L;Erickson KI;Prakash RS;Kim JS;Voss MW;Vanpatter M;Pontifex MB;Raine LB;Konkel A;Hillman CH;Cohen NJ;Kramer AF
通讯作者：
Kramer AF
DOI：
10.1523/jneurosci.6021-09.2010
发表时间：
2010-05-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Brown TI;Ross RS;Keller JB;Hasselmo ME;Stern CE
通讯作者：
Stern CE
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
DOI：
10.1249/mss.0b013e3181e9af48
发表时间：
2011-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Chaddock, Laura;Hillman, Charles H.;Cohen, Neal J.
通讯作者：
Cohen, Neal J.