Prenatal exposure to air pollution is associated with structural changes in the neonatal brain.
Prenatal exposure to air pollution is associated with structural changes in the neonatal brain.
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DOI：
10.1016/j.envint.2023.107921
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发表时间：
2023-04
影响因子：
11.8
通讯作者：
Counsell, Serena J.
中科院分区：
文献类型：
--
作者：
Bos, Brendan;Barratt, Ben;Batalle, Dafnis;Gale-Grant, Oliver;Hughes, Emer J.;Beevers, Sean;Cordero-Grande, Lucilio;Price, Anthony N.;Hutter, Jana;V. Hajnal, Joseph;Kelly, Frank J.;Edwards, David;Counsell, Serena J.
产前暴露于空气污染对新生儿脑结构的影响。在健康足月新生儿中开展的大型研究。产前空气污染暴露与脑形态改变有关。产前暴露于空气污染与儿童期不良神经系统后果有关。然而，子宫内暴露于空气污染和新生儿大脑发育之间的关系尚不清楚。我们模拟了母亲在怀孕至出生期间暴露于二氧化氮（NO2）和颗粒物（PM2.5和PM10）的邮政编码水平，并研究了产前空气污染暴露对469例（207例男性）胎龄≥36周的健康新生儿新生儿脑形态学的影响。婴儿在月经后41.29（36.71-45.14）周（PMA）接受3特斯拉MR神经成像，作为发育中的人类连接体项目（dHCP）的一部分。进行单污染物线性回归和典型相关分析（CCA），以评估空气污染和脑形态之间的关系，调整混杂因素和纠正错误发现率。较高的PM10暴露和较低的NO2暴露与较大的相对脑室容积密切相关，与小脑的相对大小中度相关。与较高的PM10暴露和较低的NO2暴露和较小的相对皮质灰质和杏仁核和海马，以及较大的相对脑干和脑外CSF体积检测到适度的关联。未发现与白色物质或深灰色核体积相关。我们的研究结果表明，产前暴露于空气污染与新生儿期脑形态学改变有关，尽管NO2和PM10的结果相反。这一发现提供了进一步的证据，表明减少孕妇在怀孕期间接触颗粒物的水平应该是公共卫生的优先事项，并强调了了解空气污染对这一关键发展窗口的影响的重要性。
Examined effects of prenatal exposure to air pollution on neonatal brain structure. Large study in healthy term born neonates. Prenatal air pollution exposure was associated with altered brain morphology. Prenatal exposure to air pollution is associated with adverse neurologic consequences in childhood. However, the relationship between in utero exposure to air pollution and neonatal brain development is unclear. We modelled maternal exposure to nitrogen dioxide (NO2) and particulate matter (PM2.5 and PM10) at postcode level between date of conception to date of birth and studied the effect of prenatal air pollution exposure on neonatal brain morphology in 469 (207 male) healthy neonates, with gestational age of ≥36 weeks. Infants underwent MR neuroimaging at 3 Tesla at 41.29 (36.71–45.14) weeks post-menstrual age (PMA) as part of the developing human connectome project (dHCP). Single pollutant linear regression and canonical correlation analysis (CCA) were performed to assess the relationship between air pollution and brain morphology, adjusting for confounders and correcting for false discovery rate. Higher exposure to PM10 and lower exposure to NO2 was strongly canonically correlated to a larger relative ventricular volume, and moderately associated with larger relative size of the cerebellum. Modest associations were detected with higher exposure to PM10 and lower exposure to NO2 and smaller relative cortical grey matter and amygdala and hippocampus, and larger relaive brainstem and extracerebral CSF volume. No associations were found with white matter or deep grey nuclei volume. Our findings show that prenatal exposure to air pollution is associated with altered brain morphometry in the neonatal period, albeit with opposing results for NO2 and PM10. This finding provides further evidence that reducing levels of maternal exposure to particulate matter during pregnancy should be a public health priority and highlights the importance of understanding the impacts of air pollution on this critical development window.
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影响因子：
48
作者：
Grandjean, Philippe;Landrigan, Philip J.
通讯作者：
Landrigan, Philip J.
DOI：
10.1016/s2542-5196(22)00200-5
发表时间：
2022-10
期刊：
The Lancet. Planetary health
影响因子：
--
作者：
Bongaerts E;Lecante LL;Bové H;Roeffaers MBJ;Ameloot M;Fowler PA;Nawrot TS
通讯作者：
Nawrot TS
影响因子：
16.6
作者：
Bove, Hannelore;Bongaerts, Eva;Nawrot, Tim S.
通讯作者：
Nawrot, Tim S.
DOI：
10.1007/s11356-014-3627-8
发表时间：
2015-03
期刊：
Environmental science and pollution research international
影响因子：
--
作者：
Jedrychowski WA;Perera FP;Camann D;Spengler J;Butscher M;Mroz E;Majewska R;Flak E;Jacek R;Sowa A
通讯作者：
Sowa A
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y