Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making.
Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making.
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识别多巴胺能和血清素能途径的新易感基因，以实现决策中的框架效应
DOI：
10.1093/scan/nsx062
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发表时间：
2017-09-01
影响因子：
4.2
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Gao X;Liu J;Gong P;Wang J;Fang W;Yan H;Zhu L;Zhou X
框架效应是指在决策过程中，当选择被正面呈现时，人们倾向于规避风险，而当同样的选择被负面呈现时，人们倾向于寻求风险。已发现这种作用受5-羟色胺转运体基因（SLC 6A 4）和儿茶酚-O-甲基转移酶基因（COMT）多态性调节，这两种基因位于多巴胺能和多巴胺能通路上，并与情感处理相关。目前的研究旨在确定多巴胺能和多巴胺能途径基因的新遗传变异，这些变异可能导致框架易感性的个体差异。利用全基因组关联数据和基于基因的主成分回归方法，我们检测了1317名中国汉族受试者的26个基因的遗传变异。与以往的研究一致，我们发现SLC 6A 4基因和COMT基因的遗传变异与框架效应相关。更重要的是，我们证明了参与多巴胺和5-羟色胺合成的芳香族-L-氨基酸脱羧酶（DDC）基因的遗传变异导致了对框架敏感性的个体差异。我们的研究结果揭示了情感决策的遗传基础的理解。
The framing effect refers the tendency to be risk-averse when options are presented positively but be risk-seeking when the same options are presented negatively during decision-making. This effect has been found to be modulated by the serotonin transporter gene (SLC6A4) and the catechol-o-methyltransferase gene (COMT) polymorphisms, which are on the dopaminergic and serotonergic pathways and which are associated with affective processing. The current study aimed to identify new genetic variations of genes on dopaminergic and serotonergic pathways that may contribute to individual differences in the susceptibility to framing. Using genome-wide association data and the gene-based principal components regression method, we examined genetic variations of 26 genes on the pathways in 1317 Chinese Han participants. Consistent with previous studies, we found that the genetic variations of the SLC6A4 gene and the COMT gene were associated with the framing effect. More importantly, we demonstrated that the genetic variations of the aromatic-L-amino-acid decarboxylase (DDC) gene, which is involved in the synthesis of both dopamine and serotonin, contributed to individual differences in the susceptibility to framing. Our findings shed light on the understanding of the genetic basis of affective decision-making.
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影响因子：
5.7
作者：
Badgaiyan, Rajendra D.;Fischman, Alan J.;Alpert, Nathaniel M.
通讯作者：
Alpert, Nathaniel M.
影响因子：
3.3
作者：
Dlugos, Andrea M.;Palmer, Abraham A.;de Wit, Harriet
通讯作者：
de Wit, Harriet
影响因子：
5.1
作者：
Dreber, Anna;Apicella, Coren L.;Campbell, Benjamin
通讯作者：
Campbell, Benjamin
影响因子：
6.8
作者：
Druckman, JN
通讯作者：
Druckman, JN
DOI：
10.1126/science.1128356
发表时间：
2006-08-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
De Martino B;Kumaran D;Seymour B;Dolan RJ
通讯作者：
Dolan RJ