Relationship between Human Pupillary Light Reflex and Circadian System Status.
Relationship between Human Pupillary Light Reflex and Circadian System Status.
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DOI：
10.1371/journal.pone.0162476
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Madrid JA
中科院分区：
文献类型：
--
作者：
Bonmati-Carrion MA;Hild K;Isherwood C;Sweeney SJ;Revell VL;Skene DJ;Rol MA;Madrid JA
视网膜内光敏性视网膜神经节细胞（ipRGC）的色素黑视蛋白在光谱的短波长范围内具有灵敏度峰值，其构成到橄榄顶盖前核（OPN）（瞳孔光反射（PLR）调节中心）和到视交叉上核（SCN）（昼夜节律系统的主要起搏器）的共同光输入通路。因此，在短波长光（λmax ≤ 500 nm）下评估PLR并创建综合PLR参数，作为间接评估昼夜节律系统状态的可能工具，变得令人感兴趣。对15名健康的年轻参与者进行了9次单色光子匹配光刺激（300 s），以10 nm的增量从λmax 420到500 nm（8只雌性），分析：i）PLR; ii）腕部温度（WT）和运动活动节律（WA），iii）光暴露（L）模式和iv）昼夜偏好（霍恩-奥斯特伯格）、睡眠质量（匹兹堡）和日间嗜睡（埃普沃思）。计算不同PLR参数与从WT、WA和L记录获得的昼夜状态指数和问卷评分之间的线性相关性。总之，我们发现了强昼夜节律的标志物，即高稳定性、降低的碎片化、高振幅、相位提前和低内部去极化，与460-490 nm波长的PLR降低相关。综合昼夜节律（CSI）和PLR（cp-PLR）参数的建议，也表现出负相关。这些结果首次证明了昼夜节律系统鲁棒性和瞳孔反射反应之间存在密切关系，这两种非视觉功能主要是在黑视素-ipRGC输入下。
Intrinsically photosensitive retinal ganglion cells (ipRGCs), whose photopigment melanopsin has a peak of sensitivity in the short wavelength range of the spectrum, constitute a common light input pathway to the olivary pretectal nucleus (OPN), the pupillary light reflex (PLR) regulatory centre, and to the suprachiasmatic nuclei (SCN), the major pacemaker of the circadian system. Thus, evaluating PLR under short wavelength light (λmax ≤ 500 nm) and creating an integrated PLR parameter, as a possible tool to indirectly assess the status of the circadian system, becomes of interest. Nine monochromatic, photon-matched light stimuli (300 s), in 10 nm increments from λmax 420 to 500 nm were administered to 15 healthy young participants (8 females), analyzing: i) the PLR; ii) wrist temperature (WT) and motor activity rhythms (WA), iii) light exposure (L) pattern and iv) diurnal preference (Horne-Östberg), sleep quality (Pittsburgh) and daytime sleepiness (Epworth). Linear correlations between the different PLR parameters and circadian status index obtained from WT, WA and L recordings and scores from questionnaires were calculated. In summary, we found markers of robust circadian rhythms, namely high stability, reduced fragmentation, high amplitude, phase advance and low internal desynchronization, were correlated with a reduced PLR to 460–490 nm wavelengths. Integrated circadian (CSI) and PLR (cp-PLR) parameters are proposed, that also showed an inverse correlation. These results demonstrate, for the first time, the existence of a close relationship between the circadian system robustness and the pupillary reflex response, two non-visual functions primarily under melanopsin-ipRGC input.
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DOI：
10.1152/ajpregu.2000.278.3.r741
发表时间：
2000-03-01
影响因子：
2.8
作者：
Kr채uchi, K;Cajochen, C;Wirz-Justice, A
通讯作者：
Wirz-Justice, A
影响因子：
64.8
作者：
Dacey, DM;Liao, HW;Gamlin, PD
通讯作者：
Gamlin, PD
影响因子：
56.9
作者：
Hattar, S;Liao, HW;Yau, KW
通讯作者：
Yau, KW
影响因子：
3.5
作者：
Brainard, George C.;Sliney, David;Rollag, Mark D.
通讯作者：
Rollag, Mark D.
影响因子：
5.8
作者：
Lockley, SW;Brainard, GC;Czeisler, CA
通讯作者：
Czeisler, CA