Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice.
Adolescent intermittent ethanol exposure induces sex-dependent divergent changes in ethanol drinking and motor activity in adulthood in C57BL/6J mice.
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青少年间歇性乙醇暴露会引起 C57BL/6J 小鼠成年期乙醇饮用和运动活动的性别依赖性不同变化。
DOI：
10.1002/jnr.24814
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发表时间：
2022-08
影响因子：
4.2
通讯作者：
Kumari A
中科院分区：
文献类型：
--
作者：
Maldonado-Devincci AM;Makdisi JG;Hill AM;Waters RC;Hall NI;Shobande MJ;Kumari A
With alcohol readily accessible to adolescents, its consumption leads to many adverse effects, including impaired learning, attention, and behavior. Adolescents report higher rates of binge drinking compared to adults. They are also more prone to substance use disorder in adulthood due to physiological changes during the adolescent developmental period. We used C57BL/6J male and female mice to investigate the long-lasting impact of binge ethanol exposure during adolescence on voluntary ethanol intake and open field behavior during later adolescence (Experiment 1) and during emerging adulthood (Experiment 2). The present set of experiments were divided into four stages: (1) adolescent intermittent vapor inhalation exposure, (2) abstinence, (3) voluntary ethanol intake, and (4) open field behavioral testing. During adolescence, male and female mice were exposed to air or ethanol using intermittent vapor inhalation from postnatal day (PND) 28–42. Following this, mice underwent short-term abstinence from PND 43–49 (Experiment 1) or protracted abstinence from PND 43–69 (Experiment 2). Beginning on PND 50–76 or PND 70–97, mice were assessed for intermittent voluntary ethanol consumption using a two-bottle drinking procedure over 28 days. Male adolescent ethanol-exposed mice showed increased ethanol consumption following short-term abstinence and following protracted abstinence. In contrast, female mice showed no changes in ethanol consumption following short-term abstinence and decreased ethanol consumption following protracted abstinence. There were modest changes in open field behavior following voluntary ethanol consumption in both experiments. These data demonstrate a sexually divergent shift in ethanol consumption following binge ethanol exposure during adolescence and differences in open field behavior. These results highlight sex-dependent vulnerability to developing substance use disorders in adulthood.
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影响因子：
3.4
作者：
Griffin, William C., III;Lopez, Marcelo F.;Yanke, Amy B.;Middaugh, Lawrence D.;Becker, Howard C.
通讯作者：
Becker, Howard C.
影响因子：
3.4
作者：
Day, Anne M.;Celio, Mark A.;Spear, Linda P.
通讯作者：
Spear, Linda P.
影响因子：
2.3
作者：
Hargreaves, Garth A.;Monds, Lauren;McGregor, Iain S.
通讯作者：
McGregor, Iain S.
DOI：
10.1111/j.1530-0277.2008.00806.x
发表时间：
2008-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Dawson DA;Goldstein RB;Chou SP;Ruan WJ;Grant BF
通讯作者：
Grant BF
DOI：
10.1016/j.jaac.2010.08.017
发表时间：
2010-12
影响因子：
13.3
作者：
Casey BJ;Jones RM
通讯作者：
Jones RM