Entrainment of the mouse circadian clock by sub-acute physical and psychological stress.
Entrainment of the mouse circadian clock by sub-acute physical and psychological stress.
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DOI：
10.1038/srep11417
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发表时间：
2015-06-15
影响因子：
4.6
通讯作者：
Shibata S
中科院分区：
文献类型：
--
作者：
Tahara Y;Shiraishi T;Kikuchi Y;Haraguchi A;Kuriki D;Sasaki H;Motohashi H;Sakai T;Shibata S
急性应激对周边昼夜节律系统的影响在体内尚不清楚。在这里，我们表明，由约束或社会失败引起的亚急性应激可能改变小鼠外周组织中的时钟基因表达。在这些外周组织以及海马体和皮层中，应激刺激诱导节律时钟基因表达模式的时间依赖性相位提前或延迟；然而，在视交叉上核（即中央生物钟）中没有观察到这种变化。此外，在光照期开始几天的应激暴露消除了昼夜节律振荡，并导致外部时钟的内部不同步。应激引起的昼夜节律变化表现为习惯化，并随着长期暴露于重复应激而消失。这些发现表明，亚急性生理/心理应激可能会干扰外周时钟，并导致体内生物钟的短暂失调。
The effects of acute stress on the peripheral circadian system are not well understood in vivo. Here, we show that sub-acute stress caused by restraint or social defeat potently altered clock gene expression in the peripheral tissues of mice. In these peripheral tissues, as well as the hippocampus and cortex, stressful stimuli induced time-of-day-dependent phase-advances or -delays in rhythmic clock gene expression patterns; however, such changes were not observed in the suprachiasmatic nucleus, i.e. the central circadian clock. Moreover, several days of stress exposure at the beginning of the light period abolished circadian oscillations and caused internal desynchronisation of peripheral clocks. Stress-induced changes in circadian rhythmicity showed habituation and disappeared with long-term exposure to repeated stress. These findings suggest that sub-acute physical/psychological stress potently entrains peripheral clocks and causes transient dysregulation of circadian clocks in vivo.
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DOI：
10.1111/nyas.12464
发表时间：
2014-01-01
期刊：
STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES II
影响因子：
--
作者：
Nicolaides, Nicolas C.;Charmandari, Evangelia;Kino, Tomoshige
通讯作者：
Kino, Tomoshige
影响因子：
5.6
作者：
Etain, B.;Milhiet, V.;Leboyer, M.
通讯作者：
Leboyer, M.
影响因子：
--
作者：
Albrecht, Urs
通讯作者：
Albrecht, Urs
影响因子：
1.7
作者：
Kinoshita, Chisato;Miyazaki, Koyomi;Ishida, Norio
通讯作者：
Ishida, Norio
DOI：
10.1016/s0889-8529(18)30191-9
发表时间：
1992-12-01
影响因子：
4.5
作者：
CHROUSOS, GP
通讯作者：
CHROUSOS, GP