Water contact angle is not a good predictor of biological responses to materials.

Water contact angle is not a good predictor of biological responses to materials.
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DOI:
10.1116/1.4989843
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发表时间:
2017-07-06
期刊:
影响因子:
2.1
通讯作者:
Williams P
Williams P
中科院分区:
工程技术4区
文献类型:
--
作者:
Alexander MR;Williams P

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通常认为,在材料表面上进行的水接触角(WCA)或其他润湿性/表面能测量可用于预测细胞对材料的附着,例如,细菌附着在疏水表面。在这篇文章中,作者提出了一个从他们的工作中出现的观点,该观点未能在大型多样性材料库中找到WCA与微生物和干细胞附着之间的关系,并与文献进行了比较,得出结论认为这种简单的规则(不幸的是)完全不足以解释细胞-材料相互作用。
Often the view is expressed that water contact angle (WCA) or other wettability/surface energy measurements made on a material surface can be used to predict cellular attachment to materials, e.g., bacteria attach to hydrophobic surfaces. In this article, the authors present a perspective emerging from their work that has failed to find relationships between WCA and microbial and stem cell attachment within large diversity material libraries and compare with the literature concluding that such simple rules are (unfortunately) wholly inadequate to explain cell–material interactions.
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