Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats.
Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats.
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DOI：
10.1155/2011/103039
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Amin ZA
中科院分区：
文献类型：
--
作者：
Alshawsh MA;Abdulla MA;Ismail S;Amin ZA
黄花正虹吸作为药用植物，在马来西亚常用于治疗肝炎和黄疸；在本研究中，应用乙醇提取物对硫代乙酰胺诱导的SD大鼠肝毒性模型进行了保肝作用的评价。将成年大鼠分为正常对照组、硫代乙酰胺(TAA)阳性对照组(肝毒性组)、水飞蓟素标准药组(保肝组)、高、低剂量组(治疗组)。治疗60d后，处死所有大鼠。与其他组相比，肝毒组的肝脏表面呈现粗糙的颗粒状，而其他组的肝脏表面则表现为光滑的一面。肝组织病理学检查证实，与正常组相比，TAA对照组大鼠血清生化指标(ALT、AST、ALP、胆红素)和肝脏丙二醛(MDA)水平显著升高，总蛋白和白蛋白水平显著降低。高剂量治疗组(2 0 0 mg/kg)可使升高的肝功能酶接近正常。本研究表明，200 mg/kg的雄蕊草提取物具有明显的保肝作用。
Orthosiphon stamineus as medicinal plant is commonly used in Malaysia for treatment of hepatitis and jaundice; in this study, the ethanol extracts were applied to evaluate the hepatoprotective effects in a thioacetamide-induced hepatotoxic model in Sprague Dawley rats. Five groups of adult rats were arranged as follows: Group 1 (normal control group), Group 2 Thioacetamide (TAA) as positive control (hepatotoxic group), Group 3 Silymarin as a well-known standard drug (hepatoprotective group), and Groups 4 and 5 as high and low dose (treatment groups). After 60-day treatment, all rats were sacrificed. The hepatotoxic group showed a coarse granulation on the liver surface when compared to the smooth aspect observed on the liver surface of the other groups. Histopathological study confirmed the result; moreover, there was a significant increase in serum liver biochemical parameters (ALT, AST, ALP, and Bilirubin) and the level of liver Malondialdehyde (MDA), accompanied by a significant decrease in the level of total protein and Albumin in the TAA control group when compared with that of the normal group. The high-dose treatment group (200 mg/kg) significantly restored the elevated liver function enzymes near to normal. This study revealed that 200 mg/kg extracts of O. stamineus exerted a hepatoprotective effect.
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影响因子：
2.7
作者：
SUMARYONO, W;PROKSCH, P;HARTMANN, T
通讯作者：
HARTMANN, T
影响因子：
5.8
作者：
Yam, M. F.;Ang, L. F.;Asmawi, M. Z.
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影响因子：
5.4
作者：
Arafat, O. M.;Tham, S. Y.;Asmawi, M. Z.
通讯作者：
Asmawi, M. Z.
DOI：
10.1016/s0731-7085(03)00227-9
发表时间：
2003-09-15
影响因子：
3.4
作者：
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通讯作者：
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影响因子：
3.8
作者：
Akowuah, GA;Zhari, I;Sadikun, A
通讯作者：
Sadikun, A