A hydrogel-based glucose affinity microsensor.
A hydrogel-based glucose affinity microsensor.
复制标题
DOI：
10.1016/j.snb.2016.03.146
复制
发表时间：
2016-12
影响因子：
8.4
通讯作者：
Lin, Qiao
中科院分区：
文献类型：
--
作者：
Shang, Junyi;Yan, Jing;Zhang, Zhixing;Huang, Xian;Maturavongsadit, Panita;Song, Bing;Jia, Yuan;Ma, Tieying;Li, Dachao;Xu, Kexin;Wang, Qian;Lin, Qiao
我们提出了一种基于水凝胶的亲和微传感器，用于连续葡萄糖测量。该微传感器基于微机电系统（MEMS）技术，并采用合成水凝胶，通过原位聚合附着在设备表面。扩散进和扩散出装置的葡萄糖分子通过亲和力结合与水凝胶中的硼酸基团可逆地结合，并导致水凝胶的介电特性发生变化，可以使用MEMS电容式换能器进行测量以确定葡萄糖浓度。原位聚合水凝胶的使用消除了其他类型的亲和微传感器中的机械移动部件，以及保持葡萄糖敏感材料所需的机械屏障，例如半透膜。这有利于微传感器的小型化和稳健运行，并且可以潜在地提高装置在皮下植入时对生物污垢的耐受性。实验结果表明，在葡萄糖浓度范围为 0–500 mg/dL 且分辨率为 0.35 mg/dL 或更高的情况下，微传感器表现出可重复和可逆的响应，并且可能可用于糖尿病护理中的连续血糖监测。
We present a hydrogel-based affinity microsensor for continuous glucose measurements. The microsensor is based on microelectromechanical systems (MEMS) technology, and incorporates a synthetic hydrogel that is attached to the device surface via in situ polymerization. Glucose molecules that diffuses into and out of the device binds reversibly with boronic acid groups in the hydrogel via affinity binding, and causes changes in the dielectric properties of the hydrogel, which can be measured using a MEMS capacitive transducer to determine the glucose concentration. The use of the in situ polymerized hydrogel eliminates mechanical moving parts found in other types of affinity microsensors, as well as mechanical barriers such as semipermeable membranes that are otherwise required to hold the glucose-sensitive material. This facilitates the miniaturization and robust operation of the microsensor, and can potentially improve the tolerance of the device, when implanted subcutaneously, to biofouling. Experimental results demonstrate that in a glucose concentration range of 0–500 mg/dL and with a resolution of 0.35 mg/dL or better, the microsensor exhibits a repeatable and reversible response, and can potentially be useful for continuous glucose monitoring in diabetes care.
登录
查看更多内容
影响因子：
12.6
作者：
Ricci, F;Moscone, D;Messeri, D
通讯作者：
Messeri, D
影响因子：
9.5
作者：
Arnold, FH;Zheng, WG;Michaels, AS
通讯作者：
Michaels, AS
影响因子：
8.4
作者：
Kuenzi, Simon;Meurville, Eric;Ryser, Peter
通讯作者：
Ryser, Peter
影响因子：
4
作者：
Huang, Xian;Li, Siqi;Lin, Qiao
通讯作者：
Lin, Qiao
DOI：
10.1109/jmems.2009.2034869
发表时间：
2009-11-13
期刊：
Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems
影响因子：
--
作者：
Huang X;Li S;Schultz J;Wang Q;Lin Q
通讯作者：
Lin Q