Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions.
Brain-wide mapping reveals that engrams for a single memory are distributed across multiple brain regions.
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DOI：
10.1038/s41467-022-29384-4
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发表时间：
2022-04-04
影响因子：
16.6
通讯作者：
Tonegawa S
中科院分区：
文献类型：
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作者：
Roy DS;Park YG;Kim ME;Zhang Y;Ogawa SK;DiNapoli N;Gu X;Cho JH;Choi H;Kamentsky L;Martin J;Mosto O;Aida T;Chung K;Tonegawa S
在海马体、杏仁核或皮层中已经发现了保存特定记忆（记忆痕迹）的神经元集合。然而，有人假设特定记忆的痕迹分布在功能上相连的多个大脑区域中，称为统一的痕迹复合体。在这里，我们报告了一个部分地图的记忆印迹复杂的上下文恐惧条件记忆的特征编码激活的神经元合奏在247个区域中使用组织表型小鼠。该映射由记忆印迹指数辅助，该指数确定了117个具有高概率记忆印迹的cFos+脑区域，以及通过回忆对这些神经元集合的全脑重新激活。光遗传学操作实验揭示了记忆痕迹，其中许多功能连接到海马或杏仁核记忆痕迹。同时化学遗传再激活的多个印迹合奏赋予了更高水平的记忆回忆比再激活一个单一的印迹合奏，反映了自然的记忆回忆过程。总的来说，我们的研究支持记忆储存的统一记忆印迹复合体假设。记忆在我们大脑中的位置还不清楚。在这篇论文中，作者证明了记忆分布在多个大脑区域。
Neuronal ensembles that hold specific memory (memory engrams) have been identified in the hippocampus, amygdala, or cortex. However, it has been hypothesized that engrams of a specific memory are distributed among multiple brain regions that are functionally connected, referred to as a unified engram complex. Here, we report a partial map of the engram complex for contextual fear conditioning memory by characterizing encoding activated neuronal ensembles in 247 regions using tissue phenotyping in mice. The mapping was aided by an engram index, which identified 117 cFos+ brain regions holding engrams with high probability, and brain-wide reactivation of these neuronal ensembles by recall. Optogenetic manipulation experiments revealed engram ensembles, many of which were functionally connected to hippocampal or amygdala engrams. Simultaneous chemogenetic reactivation of multiple engram ensembles conferred a greater level of memory recall than reactivation of a single engram ensemble, reflecting the natural memory recall process. Overall, our study supports the unified engram complex hypothesis for memory storage. Where memories are located in our brains is not well understood. In this paper, the authors demonstrate that memories are spread out throughout multiple brain regions.
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影响因子：
5.7
作者：
Morrison SE;Salzman CD
通讯作者：
Salzman CD
影响因子：
64.8
作者：
Roy DS;Arons A;Mitchell TI;Pignatelli M;Ryan TJ;Tonegawa S
通讯作者：
Tonegawa S
影响因子：
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作者：
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影响因子：
64.8
作者：
Janak PH;Tye KM
通讯作者：
Tye KM
影响因子：
64.8
作者：
通讯作者：
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