Re-valuing the amygdala.

Re-valuing the amygdala.
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DOI:
10.1016/j.conb.2010.02.007
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发表时间:
2010-04
影响因子:
5.7
通讯作者:
Salzman CD
Salzman CD
中科院分区:
医学2区
文献类型:
--
作者:
Morrison SE;Salzman CD

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最近的进展表明,杏仁核代表价:一个一般的欲望/厌恶情感特征,承担类似的神经经济学的价值概念。神经生理学研究表明,单个杏仁核神经元对一系列具有积极或消极情感意义的刺激有不同的反应。与此同时,越来越多的特异性损伤/失活研究表明,杏仁核是过程所必需的-例如,害怕灭绝和更大的贬值--这涉及到更新价值的表现。此外,最近的神经影像学研究表明,人类杏仁核介导许多基于奖励的决策任务的表现。杏仁核对情感意义的编码最好被描述为状态值的表征--这种表征有助于协调情感/情绪背景下的生理、行为和认知反应。
Recent advances indicate that the amygdala represents valence: a general appetitive/aversive affective characteristic that bears similarity to the neuroeconomic concept of value. Neurophysiological studies show that individual amygdala neurons respond differentially to a range of stimuli with positive or negative affective significance. Meanwhile, increasingly specific lesion/inactivation studies reveal that the amygdala is necessary for processes – e.g., fear extinction and reinforcer devaluation – that involve updating representations of value. Furthermore, recent neuroimaging studies suggest that the human amygdala mediates performance on many reward-based decision-making tasks. The encoding of affective significance by the amygdala might be best described as a representation of state value – a representation that is useful for coordinating physiological, behavioral, and cognitive responses in an affective/emotional context.
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