Frequency-dependent modulation of cerebellar excitability during the application of non-invasive alternating current stimulation.
Frequency-dependent modulation of cerebellar excitability during the application of non-invasive alternating current stimulation.
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非侵入性交流电刺激过程中小脑兴奋性的频率依赖性调节。
DOI：
10.1016/j.brs.2021.01.007
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发表时间：
2021-03
影响因子：
7.7
通讯作者：
Rocchi L
中科院分区：
文献类型：
--
作者：
Spampinato D;Avci E;Rothwell J;Rocchi L
众所周知，小脑对于运动和认知动作的完整性至关重要。在该区域应用非侵入性脑刺激技术会导致神经生理和行为变化，这些变化与小脑-大脑皮层连接的调节有关。在这里，我们调查了是否在线应用小脑经颅交流电刺激（tACS）的结果，这一途径的变化。13名健康个体参与了以不同频率（5 Hz和50 Hz）递送的两次小脑tACS。我们使用经颅磁刺激测量小脑运动皮层（M1）抑制（CBI），短皮质内抑制（SICI）和短传入抑制（SAI）之前，期间和之后的应用tACS。我们发现，在应用5 Hz小脑tACS期间，CBI特异性增强。在施加5 Hz刺激后立即未检测到变化，在50 Hz刺激的任何时间点也未检测到变化。我们还发现M1皮质内回路（即SICI）或感觉运动相互作用（即SAI）没有变化，表明5 Hz tACS对小脑的影响具有位点特异性。小脑tACS可以以时间和频率依赖性的方式调节小脑的兴奋性。此外，小脑tACS似乎不会诱导任何持久的影响（即可塑性），这表明刺激仅在整个刺激期间增强小脑内的振荡。因此，小脑tACS可能对表现为异常小脑振荡活动的疾病以及未来的行为研究具有重要意义。小脑tACS增加小脑对M1（CBI）施加的抑制性张力。仅在在线应用5 Hz tACS期间发现CBI变化，而不是在刺激后立即发现。这些影响是小脑特有的，因为在皮质内测量（例如SICI和SAI）中没有发现变化。
it is well-known that the cerebellum is critical for the integrity of motor and cognitive actions. Applying non-invasive brain stimulation techniques over this region results in neurophysiological and behavioural changes, which have been associated with the modulation of cerebellar-cerebral cortex connectivity. Here, we investigated whether online application of cerebellar transcranial alternating current stimulation (tACS) results in changes to this pathway. thirteen healthy individuals participated in two sessions of cerebellar tACS delivered at different frequencies (5Hz and 50Hz). We used transcranial magnetic stimulation to measure cerebellar-motor cortex (M1) inhibition (CBI), short-intracortical inhibition (SICI) and short-afferent inhibition (SAI) before, during and after the application of tACS. we found that CBI was specifically strengthened during the application of 5Hz cerebellar tACS. No changes were detected immediately following the application of 5Hz stimulation, nor at any time point with 50Hz stimulation. We also found no changes to M1 intracortical circuits (i.e. SICI) or sensorimotor interaction (i.e. SAI), indicating that the effects of 5Hz tACS over the cerebellum are site-specific. cerebellar tACS can modulate cerebellar excitability in a time- and frequency-dependent manner. Additionally, cerebellar tACS does not appear to induce any long-lasting effects (i.e. plasticity), suggesting that stimulation enhances oscillations within the cerebellum only throughout the stimulation period. As such, cerebellar tACS may have significant implications for diseases manifesting with abnormal cerebellar oscillatory activity and also for future behavioural studies. Cerebellar tACS increases the inhibitory tone that the cerebellum exerts over M1 (CBI). CBI changes were found only during the online application of 5Hz tACS and not immediately following stimulation. The effects are specific to the cerebellum, as no changes were found in intracortical measures (e.g. SICI and SAI).
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DOI：
10.1523/jneurosci.2184-09.2009
发表时间：
2009-07-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Galea JM;Jayaram G;Ajagbe L;Celnik P
通讯作者：
Celnik P
影响因子：
4.6
作者：
Casula EP;Pellicciari MC;Ponzo V;Stampanoni Bassi M;Veniero D;Caltagirone C;Koch G
通讯作者：
Koch G
影响因子：
16.2
作者：
Dugue, Guillaume P.;Brunel, Nicolas;Dieudonne, Stephane
通讯作者：
Dieudonne, Stephane
影响因子：
9.2
作者：
Joundi, Raed A.;Jenkinson, Ned;Brittain, John-Stuart;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
2.9
作者：
Antal A;Paulus W
通讯作者：
Paulus W