Olfactory Function in SCA10.
Olfactory Function in SCA10.
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DOI：
10.1007/s12311-018-0954-1
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发表时间：
2019-03
期刊：
影响因子：
--
通讯作者：
Silveira-Moriyama L
中科院分区：
文献类型：
--
作者：
Moscovich M;Munhoz RP;Moro A;Raskin S;McFarland K;Ashizawa T;Teive HAG;Silveira-Moriyama L
虽然脊髓小脑共济失调（SCA）的主要临床表现是小脑及其连接的损伤，但也可能涉及其他系统。到目前为止，还没有关于SCA 10型（SCA 10）嗅觉缺陷的研究。然而，尽管仍有争议，嗅觉缺陷已报告在其他类型的遗传性共济失调，特别是SCA 3，世界范围内最普遍的形式SCA。嗅觉识别在三组30名患者（SCA 10、SCA 3和帕金森病- PD）和一组44名健康对照中使用Sniffin' Sticks（SS 16）测试进行测试。SCA 10组的平均病程为14.2 ± 11年，SCA 3组为11.3 ± 6年。SCA 10组的平均SS 16评分为11.9 ± 2.9，SCA 3组为12.3 ± 1.9，PD组为6.6 ± 2.8，对照组为12.1 ± 2.0。SCA 10组的平均SS 16评分与SCA 3组和对照组的评分无显著差异，但在调整年龄、性别和吸烟史后，显著高于PD组的评分（p < 0.001）。在SCA 10或SCA 3组中，SS 16评分与疾病持续时间（p>0.05）或重复扩增次数（17例SCA 10患者p = 0.7，14例SCA 3患者p = 0.3）之间没有相关性。三组患者的SS 16和简易精神状态检查量表评分高度相关：SCA 10组（r=0.59，p = 0.001）、SCA 3组（r=0.50，p = 0.005）和对照组（r=0.40，p = 0.007）。我们发现在这个大的系列SCA 10没有显着的嗅觉缺陷。
Although the main clinical manifestations of spinocerebellar ataxias (SCAs) result from damage of the cerebellum and its connections, other systems may also be involved. To date, there are no studies on olfactory deficits in SCA type 10 (SCA10). However, although still controversy, olfactory deficits have been reported in other types of hereditary ataxias, especially SCA3, the most prevalent form of SCA worldwide. Olfactory identification was tested in three groups of 30 patients (SCA10, SCA3 and Parkinson’s disease - PD) and a group of 44 healthy controls using the Sniffin’ Sticks (SS16) test. Mean disease duration was 14.2 ± 11 years in the SCA10 group and 11.3 ± 6 years in the SCA3 group. Mean SS16 score was 11.9 ± 2.9 for the SCA10 group, 12.3 ± 1.9 for the SCA3 group, 6.6 ± 2.8 for the PD group and 12.1 ± 2.0 for the control group. Mean SS16 score for the SCA10 group was not significantly different from the scores for the SCA3 and control groups but was significantly higher than the score for the PD group (p < 0.001) when adjusted for age, gender and history of smoking. There was no association between SS16 scores and disease duration in the SCA10 or SCA3 groups (p>0.05) or number of repeat expansions (p = 0.7 for 17 SCA10 patients and p = 0.3 for 14 SCA3 patients). SS16 and Mini Mental State Examination scores were highly correlated in the three groups: SCA10 group (r=0.59, p = 0.001), SCA3 group (r=0.50, p = 0.005) and control group (r=0.40, p = 0.007). We found no significant olfactory deficits in SCA10 in this large series.
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影响因子：
--
作者：
Paulson, Henry
通讯作者：
Paulson, Henry
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
2.5
作者：
Qureshy, A;Kawashima, R;Fukuda, H
通讯作者：
Fukuda, H
影响因子：
8.6
作者：
Silveira-Moriyama, Laura;Hughes, Graham;Lees, Andrew J.
通讯作者：
Lees, Andrew J.
DOI：
10.1016/0168-5597(92)90070-r
发表时间：
1992-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
HUMMEL, T;KOBAL, G
通讯作者：
KOBAL, G