Serum Levels of Vitamin D and Dental Caries in 7-Year-Old Children in Porto Metropolitan Area.
Serum Levels of Vitamin D and Dental Caries in 7-Year-Old Children in Porto Metropolitan Area.
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DOI：
10.3390/nu13010166
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发表时间：
2021-01-07
期刊：
影响因子：
5.9
通讯作者：
Melo P
中科院分区：
文献类型：
--
作者：
Carvalho Silva C;Gavinha S;Manso MC;Rodrigues R;Martins S;Guimarães JT;Santos AC;Melo P
维生素D缺乏与牙齿结构的显著变化有关。在儿童中，它可以诱发牙釉质和牙本质缺陷，这已被确定为龋齿的危险因素。本研究旨在评估7岁儿童血清25-羟基维生素D （25(OH) D）低水平（<30 ng/mL）与恒牙和混合牙列龋患病率之间的关系。从以人口为基础的出生队列第21代（波尔图，葡萄牙）中选取335名儿童作为样本。收集了儿童人口和社会状况、健康状况、牙齿健康行为、牙齿检查（包括萌出的第一恒磨牙）以及可用于维生素D分析的血液样本等数据。牙齿结果包括是否存在龋齿，包括非空化病变（d1-6mft / d1-6mft >）和晚期龋齿（d3-6mft / D3-6MF >）。采用竞争性电化学发光免疫分析法测定血清25(OH) D蛋白结合。采用双因素分析和多因素logistic回归。永久性牙齿的晚期龋与儿童维生素D水平<30 ng/mL、胃肠道疾病、每日摄入较高的致龋食物以及≤7岁时就诊有显著相关。儿童时期维生素D的最佳水平可以被认为是预防恒牙龋齿的额外措施。
Vitamin D deficiency has been associated with significant changes in dental structures. In children, it can induce enamel and dentin defects, which have been identified as risk factors for caries. This study aimed to assess the association between low serum 25-hydroxyvitamin D (25(OH) D) levels (<30 ng/mL) and the prevalence of caries in the permanent teeth and mixed dentition of 7-year-old children. A sample of 335 children from the population-based birth cohort Generation XXI (Porto, Portugal) was included. Data on children’s demographic and social conditions, health status, dental health behaviours, dental examination including erupted permanent first molars, and blood samples available for vitamin D analysis were collected. Dental outcomes included the presence of caries, including non-cavitated lesions (d1–6mft/D1–6MFT > 0), and advanced caries (d3–6mft/D3–6MF > 0). Serum 25(OH) D was measured using a competitive electrochemiluminescence immunoassay protein-binding assay. Bivariate analysis and multivariate logistic regression were used. Advanced caries in permanent teeth was significantly associated with children’s vitamin D levels <30 ng/mL, gastrointestinal disorders, higher daily intake of cariogenic food, and having had a dental appointment at ≤7 years old. Optimal childhood levels of vitamin D may be considered an additional preventive measure for dental caries in the permanent dentition.
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DOI：
10.1097/mpg.0b013e31828f3c05
发表时间：
2013-06-01
影响因子：
2.9
作者：
Braegger, Christian;Campoy, Cristina;van Goudoever, Johannes
通讯作者：
van Goudoever, Johannes
影响因子：
5.4
作者：
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通讯作者：
Lopes, Carla
影响因子：
2.9
作者：
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Oh HW
影响因子：
2.3
作者：
Ju, Xiangqun;Jamieson, Lisa M.;Mejia, Gloria C.
通讯作者：
Mejia, Gloria C.
DOI：
10.3945/ajcn.115.120873
发表时间：
2016-04
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Cashman KD;Dowling KG;Škrabáková Z;Gonzalez-Gross M;Valtueña J;De Henauw S;Moreno L;Damsgaard CT;Michaelsen KF;Mølgaard C;Jorde R;Grimnes G;Moschonis G;Mavrogianni C;Manios Y;Thamm M;Mensink GB;Rabenberg M;Busch MA;Cox L;Meadows S;Goldberg G;Prentice A;Dekker JM;Nijpels G;Pilz S;Swart KM;van Schoor NM;Lips P;Eiriksdottir G;Gudnason V;Cotch MF;Koskinen S;Lamberg-Allardt C;Durazo-Arvizu RA;Sempos CT;Kiely M
通讯作者：
Kiely M