Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project.
Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project.
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DOI：
10.1001/archpediatrics.2010.163
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发表时间：
2010-09
影响因子：
--
通讯作者：
Ducatman, Alan M.
中科院分区：
文献类型：
--
作者：
Frisbee, Stephanie J.;Shankar, Anoop;Knox, Sarah S.;Steenland, Kyle;Savitz, David A.;Fletcher, Tony;Ducatman, Alan M.
全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）是广泛存在于人类血清中的人造化合物。在以前的职业和成人研究中，全氟辛烷磺酸和全氟辛烷磺酸与血脂呈正相关。我们的目的是询问全氟辛烷磺酸和全氟辛烷磺酸与儿童血脂之间的关系。横断面社区研究。俄亥俄州中部河谷。12 476名儿童被纳入C8健康项目，这是根据饮用水供应受到全氟辛酸污染而提起的集体诉讼的审前和解结果。血脂（总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和空腹甘油三酯）。血清PFOA和PFOS平均浓度分别为69.2±111.9 ng/mL和22.7±12.6 ng/mL。在调整协变量后的线性回归中，PFOA与总胆固醇和LDL胆固醇升高显著相关，PFOS与总胆固醇、HDL胆固醇和LDL胆固醇升高显著相关。在GLM ANCOVA分析中，在PFOA的第1 - 5分位数之间，总胆固醇和低密度脂蛋白胆固醇的调整平均值分别增加4.6 mg/dL和3.8 mg/dL，在PFOS的第1 - 5分位数之间，总胆固醇和低密度脂蛋白胆固醇的调整平均值分别增加8.5 mg/dL和5.8 mg/dL。在某些年龄和性别阶层中增加了10 mg/dL。观察到的影响是非线性的，总胆固醇和低密度脂蛋白胆固醇的增加较大，特别是PFOA的最低范围。虽然当前研究的流行病学和横断面性质限制了因果推论，但观察到的PFOA和PFOS增加与总胆固醇和低密度脂蛋白胆固醇升高之间的一致关联值得进一步研究。
Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are man-made compounds with widespread presence in human sera. In previous occupational and adult studies, PFOA and PFOS have been positively associated with serum lipids. Our objective is to interrogate the association between PFOA and PFOS and serum lipids in children. Cross-sectional community-based study. Mid-Ohio river valley. 12,476 children included in the C8 Health Project, resultant from the pre-trial settlement of a class action lawsuit pursuant to PFOA contamination of the drinking water supply. Serum lipids (total, HDL, and LDL cholesterol, and fasting triglycerides). Mean serum PFOA and PFOS concentrations were 69.2±111.9 ng/mL and 22.7±12.6 ng/mL. In linear regression after adjustment for covariables, PFOA was significantly associated with increased total and LDL cholesterol, and PFOS was significantly associated with increased total, HDL, and LDL cholesterol. In GLM ANCOVA analysis, between the 1st—5th quintiles of PFOA there was a 4.6 mg/dL and 3.8 mg/dL increase in the adjusted mean of total and LDL cholesterol, and an 8.5 mg/dL and 5.8 mg/dL increase in the adjusted mean for total and LDL cholesterol between the 1st—5th quintiles of PFOS. Increases were 10 mg/dL for some age- and gender-group strata. Observed effects were non-linear, with larger increases in total and LDL cholesterol occurring the lowest range of particularly PFOA. While the epidemiologic and cross-sectional nature of the current study limit causal inferences, the consistent observed associations between increasing PFOA and PFOS and elevated total and LDL cholesterol warrant further study.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
10.4
作者：
Kärrman A;Ericson I;van Bavel B;Darnerud PO;Aune M;Glynn A;Lignell S;Lindström G
通讯作者：
Lindström G
DOI：
10.1097/01.jom.0000233380.13087.37
发表时间：
2006-08-01
影响因子：
3.2
作者：
Emmett, Edward Anthony;Zhang, Hong;Shaw, Leslie Michael
通讯作者：
Shaw, Leslie Michael
DOI：
10.1016/s1388-1981(99)00024-4
发表时间：
1999-03-25
影响因子：
4.8
作者：
Okochi, E;Nishimaki-Mogami, T;Takahashi, A
通讯作者：
Takahashi, A
影响因子：
2.6
作者：
Hundley, SG;Sarrif, AM;Kennedy, GL
通讯作者：
Kennedy, GL