Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats.
Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats.
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DOI：
10.1016/j.physbeh.2010.11.005
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发表时间：
2011-02-01
影响因子：
2.9
通讯作者：
Pillai, Anilkumar
中科院分区：
文献类型：
--
作者：
Terry, Alvin V., Jr.;Kutiyanawalla, Ammar;Pillai, Anilkumar
本研究的目的是评估衰老对大鼠特定记忆相关任务的影响，以及确定相关脑区中几种神经生长因子（NGF）相关蛋白的水平。结果表明，在水迷宫任务中的空间学习的年龄相关的损害，以及在自发的新物体识别任务中的识别记忆的赤字。在前额叶皮层和海马中，老年大鼠（与年轻对照组相比）的前神经营养因子、proNGF（+1.8-1.9倍）、p75 NTR受体（+1.6-1.8倍）和分拣蛋白（+1.8-2.1倍）水平升高，成熟NGF（-36-44%）和磷酸化TrkA受体（-45-49%）水平降低。这项研究的结果支持了这样一种观点，即NGF信号在衰老的大脑中发生了改变，这种改变可能导致与年龄相关的认知功能下降。这些结果还可能有助于鉴定NGF信号传导途径的特定组分，其可以作为用于年龄相关认知障碍的新药发现和开发的靶标（例如，阿尔茨海默病）。
The objective of this study was to evaluate the effects of aging on the performance of specific memory-related tasks in rats as well as to determine the levels of several nerve growth factor (NGF)-related proteins in relevant brain regions. The results indicated age-related impairments in spatial learning in a water maze task as well as deficits in recognition memory in a Spontaneous Novel Object Recognition task. In the prefrontal cortex and hippocampus, aged rats (compared to young controls) had elevated levels of the proneurotrophin, proNGF (+1.8–1.9 fold), p75NTR receptors (+1.6–1.8 fold) and sortilin (+1.8–2.1 fold), and decreased levels of mature NGF (−36–44%), and phospho-TrkA receptors (−45–49%). The results of this study support the argument that NGF signaling is altered in the aging brain, and that such alterations may contribute to an age-related decline in cognitive function. These results may also help to identify specific components of the NGF-signaling pathway that could serve as targets for novel drug discovery and development for age-related disorders of cognition (e.g., Alzheimer’s disease).
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