Cytokine gene polymorphisms associate with microbiogical agents in periodontal disease: our experience.
Cytokine gene polymorphisms associate with microbiogical agents in periodontal disease: our experience.
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细胞因子基因多态性与牙周病微生物制剂相关：我们的经验。
DOI：
10.7150/ijms.6962
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发表时间：
2014
影响因子：
3.6
通讯作者：
De Vito D
中科院分区：
文献类型：
--
作者：
Cantore S;Mirgaldi R;Ballini A;Coscia MF;Scacco S;Papa F;Inchingolo F;Dipalma G;De Vito D
牙周病已经从一个简单的模型发展到感染和宿主反应之间更复杂的相互作用。遗传因素已成为牙周病危险因素列表中的新成员。导致被破坏组织的破坏和再生的过程是研究人员和临床医生都非常感兴趣的。受试者对牙周炎的选择性易感性仍然是一个谜，各种各样的危险因素与牙周炎的表现和进展有关。新兴的途径模型表明，基因-环境相互作用在疾病发病机制中具有重要的病因学意义。目前牙周炎遗传知识的实用性是有限的。多个基因位点的等位基因变异可能影响牙周炎的易感性。促炎细胞因子白细胞介素-1（IL-1）是宿主对微生物感染的反应的关键调节剂，也是细胞外基质分解和骨吸收的主要调节剂，并且IL-1基因簇中的多态性与发展严重成人牙周炎的风险增加相关。本研究的目的是在一个病例对照研究人群中，结合微生物结果，检测IL-1 α +4845和IL-1 β +3954基因多态性是否与牙周炎相关。IL-1 α +4845和IL-1 β +3954单核苷酸多态性（SNP）在研究组（健康对照组、轻度、中度和重度牙周炎组，p <0.05，d.f.= 0.001）中观察到的多态性存在显著差异。1.我们发现重度牙周炎与复合基因型的存在有显著相关性（p <0.05，d.f.= 0.001）。1，在健康与重度之间计算）。此外，检测到细菌的存在与牙周炎之间的统计学显著关联（p <0.05，d.f.= 0.0001）。1）。在当前的调查中，结果与文献观察结果一致。
Periodontics has evolved from a simplistic model to a more complex interplay between infection and host response. Genetic factors have been a new addition to the list of risk factors for periodontal diseases. The processes leading to destruction and regeneration of the destroyed tissues are of great interest to both researchers and clinicians. The selective susceptibility of subjects for periodontitis has remained an enigma and wide varieties of risk factors have been implicated for the manifestation and progression of periodontitis. Emerging pathway models suggest that gene-environment interactions are etiologically important in disease pathogenesis. The current practical utility of genetic knowledge in periodontitis is limited. Allelic variants at multiple gene loci probably influence periodontitis susceptibility. The pro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption, and polymorphisms in the IL-1 gene cluster have been associated with an increased risk of developing severe adult periodontitis. The aim of this study was to test if polymorphisms of genes of IL-1α+4845 and IL-1β +3954 were linked with periodontitis, in a case-control study population, delimited to a specific geographic area, in association with microbiological findings. The polymorphisms observed in IL-1α+4845 and IL-1β+3954 single nucleotide polymorphisms (SNPs), was significantly different among the study groups (healthy controls, mild, moderate and severe periodontitis with p<0.05, d.f.=1. We found a significant correlation between the severe form of periodontitis and the presence of composite genotype (p < 0.05, d.f.=1, calculated among healthy vs. severe). Furthermore a statistically significant association between the presence of bacteria and periodontitis was detected (p<0.05, d.f.=1). In the current investigation findings were concordant with literature observations.
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