Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2.
Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2.
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DOI：
10.1039/c8ra02430h
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发表时间：
2018-04-18
期刊：
影响因子：
3.9
通讯作者：
Liu, Hongju
中科院分区：
文献类型：
--
作者：
Yan, Chong;Liu, Weiyang;Li, Jing;Deng, Yanlian;Chen, Senhua;Liu, Hongju
从檀香（Santalum album）枝条内生真菌Fusariumsp. YD-2中分离得到2个新的螺萜类化合物，即fusariumin A（1）和B（2），沿着4个已知的萜类化合物，分别为asperterpenoid A（3），agathic acid（4），guignardone N（5）和trametenolic acid（6）。它们的结构通过光谱分析的组合进行了鉴定。1的绝对构型由单晶X-射线衍射确定，2的绝对构型由实验和计算的电子圆二色光谱确定.化合物2通过抑制脂多糖激活的RAW264.7细胞中的一氧化氮（NO）产生而显示出中等的体外抗炎活性，IC 50值为50 μM，化合物3显示出强的抗炎活性，IC 50值为1.6 μM。在抗菌试验中，化合物1显示出对金黄色葡萄球菌和铜绿假单胞菌的显著活性，MIC值为6.3 μg mL-1，化合物3显示出对沙门氏菌和藤黄微球菌的中等活性，MIC值分别为6.3和25.2 μg mL-1。从檀香（Santalum album）枝条内生真菌Fusariumsp. YD-2中分离得到2个新的螺萜类化合物，即fusariumin A（1）和B（2），沿着4个已知的萜类化合物，分别为asperterpenoid A（3），agathic acid（4），guignardone N（5）和trametenolic acid（6）。
Two new spiromeroterpenoids, namely fusariumin A (1) and B (2), along with four known terpenoids, asperterpenoid A (3), agathic acid (4), guignardone N (5), and trametenolic acid (6), were obtained from the endophytic fungus Fusarium sp. YD-2, derived from the twigs of Santalum album. Their structures were elucidated by a combination of spectroscopic analyses. The absolute configuration of 1 was determined by single-crystal X-ray diffraction using Cu Kα radiation, and that of 2 was elucidated on the basis of experimental and calculated electronic circular dichroism spectra. Compound 2 exhibited moderate anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with an IC50 value of 50 μM, and compound 3 showed strong anti-inflammatory activity with an IC50 value of 1.6 μM. In the antibacterial assay, compound 1 displayed significant activities against Staphylococcus aureus and Pseudomonas aeruginosa with an MIC value of 6.3 μg mL−1, and compound 3 showed moderate activities against Salmonella enteritidis and Micrococcus luteus with MIC values of 6.3 and 25.2 μg mL−1, respectively. Two new spiromeroterpenoids, namely fusariumin A (1) and B (2), along with four known terpenoids, asperterpenoid A (3), agathic acid (4), guignardone N (5), and trametenolic acid (6), were obtained from the endophytic fungus Fusarium sp. YD-2, derived from the twigs of Santalum album.
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影响因子：
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