Association of invitation to lung cancer screening and tobacco use outcomes in a VA demonstration project.
Association of invitation to lung cancer screening and tobacco use outcomes in a VA demonstration project.
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在 VA 示范项目中邀请肺癌筛查和烟草使用结果协会。
DOI：
10.1016/j.pmedr.2019.101023
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发表时间：
2019
影响因子：
2.8
通讯作者：
Partin,MelissaR
中科院分区：
文献类型：
--
作者：
Fu,StevenS;Melzer,AnneC;Fabbrini,AngelaE;Rice,KathrynL;Clothier,Barbara;Nelson,DavidB;Doro,ElizabethA;Partin,MelissaR
肺癌筛查（LCS）的一个潜在的意外后果是对吸烟行为的不利影响。这在以前的随机临床试验中很难评估。我们的目标是确定直接邀请（DI）参加LCS的退伍军人与常规护理（UC）之间的戒烟和复发行为是否不同。我们对2014年至2015年退伍军人（明尼阿波利斯VA）的烟草使用结局进行了纵向调查，随机（2：1）分配至DI与UC，并按基线吸烟状态（当前/既往）分层。在DI组中，我们探讨了选择和不选择接受LCS的患者之间的差异。共有979例患者（n = 660例DI，n = 319例UC）在中位484天返回调查。在当前吸烟者（n = 488）中，DI组和UC组的戒烟率和戒烟尝试没有差异。与UC患者相比，DI患者中更多的基线吸烟者在随访时为非每日吸烟者（25.3% vs 15.6%，OR 1.97 95%CI 1.15-3.36）。基线时有相当比例的前吸烟者复发，总体上有17%的人表示过去30天吸烟。这在武器之间没有区别。在被邀请参加LCS的人中，选择接受筛查（161/660）与不接受筛查的人之间的吸烟结果没有显著差异。在邀请LCS的背景下对吸烟行为进行的这项随机化项目评估观察到，在邀请LCS的参与者或完成筛选的参与者中，对戒烟或复吸没有不利或有益的影响。随着LCS计划在全国范围内的扩展和推广，有效的戒烟计划将至关重要。
A potential unintended consequence of lung cancer screening (LCS) is an adverse effect on smoking behaviors. This has been difficult to assess in previous randomized clinical trials. Our goal was to determine whether cessation and relapse behaviors differ between Veterans directly invited (DI) to participate in LCS compared to usual care (UC). We conducted a longitudinal survey of tobacco use outcomes among Veterans (Minneapolis VA) from 2014 to 2015, randomized (2:1) to DI versus UC and stratified by baseline smoking status (current/former). Within the DI group, we explored differences between those who did and did not choose to undergo LCS. A total of 979 patients (n = 660 DI, n = 319 UC) returned the survey at a median of 484 days. Among current smokers (n = 488), smoking abstinence rates and cessation attempts did not differ between DI and UC groups. More baseline smokers in DI were non-daily smokers at follow-up compared to those in UC (25.3% vs 15.6%, OR 1.97 95%CI 1.15–3.36). A significant proportion of former smokers at baseline relapsed, with 17% overall indicating past 30-day smoking. This did not differ between arms. Of those invited to LCS, smoking outcomes did not significantly differ between those who chose to be screened (161/660) versus not. This randomized program evaluation of smoking behaviors in the context of invitation to LCS observed no adverse or beneficial effects on tobacco cessation or relapse among participants invited to LCS, or among those who completed screening. As LCS programs scale and spread nationally, effective cessation programs will be essential.
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影响因子：
--
作者：
W. Coryell;M. Zimmerman
通讯作者：
M. Zimmerman
精神分裂症、分裂情感性精神病和情感障碍。
影响因子：
6.6
作者：
C. Scharfetter;M. Nüsperli
通讯作者：
M. Nüsperli
精神分裂症的随访和家庭研究。
影响因子：
--
作者：
S. Guze;C. Robert Cloninger;R. Martin;P. Clayton
通讯作者：
P. Clayton
未能在精神分裂症先证者的一级亲属中找到精神分裂症的证据。
DOI：
10.1176/ajp.139.6.826
发表时间：
1982
期刊：
The American journal of psychiatry
影响因子：
--
作者：
H. Pope;J. Jonas;B. Cohen;J. Lipinski
通讯作者：
J. Lipinski
精神分裂症和正常对照先证者的家庭研究：对精神分裂症谱系概念的影响。
DOI：
10.1176/ajp.142.4.447
发表时间：
1985
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Baron,M;Gruen,R;Rainer,JD;Kane,J;Asnis,L;Lord,S
通讯作者：
Lord,S