Orthopedic interface tissue engineering for the biological fixation of soft tissue grafts.
Orthopedic interface tissue engineering for the biological fixation of soft tissue grafts.
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DOI：
10.1016/j.csm.2008.08.006
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发表时间：
2009-01
影响因子：
2
通讯作者：
Lu, Helen H.
中科院分区：
文献类型：
--
作者：
Moffat, Kristen L.;Wang, I-Ning Elaine;Rodeo, Scott A.;Lu, Helen H.
关键词：
界面组织工程是一种很有前途的新策略，旨在组织界面的再生，并最终实现用于骨科修复和运动医学的软组织移植物的生物固定。许多直接植入软骨下骨的韧带和肌腱表现出复杂的末端，由几个不同但连续的软组织区域、未钙化的纤维软骨、钙化的纤维软骨和骨组成。这种多组织界面的再生对于功能移植物的整合和改善长期的临床结果至关重要。本文将着重介绍界面结构与功能的关系、界面再生的机制，以及在界面组织工程和多组织再生的层状支架设计中实施的战略性生物仿生学。还将讨论这一新兴领域的潜在挑战和未来方向。预计界面组织工程将导致新一代软组织修复一体化固定装置的设计，并将有助于开发具有仿生复杂性和功能性的集成化肌肉骨骼组织系统。
Interface tissue engineering is a promising new strategy aimed at the regeneration of tissue interfaces and ultimately enabling the biological fixation of soft tissue grafts utilized in orthopaedic repair and sports medicine. Many ligaments and tendons with direct insertions into subchondral bone exhibit a complex enthesis consisting of several distinct yet continuous regions of soft tissue, noncalcified fibrocartilage, calcified fibrocartilage and bone. Regeneration of this multi-tissue interface will be critical for functional graft integration and improving long term clinical outcome. This review will highlight current knowledge of the structure-function relationship at the interface, the mechanism of interface regeneration, and the strategic biomimicry implemented in stratified scaffold design for interface tissue engineering and multi-tissue regeneration. Potential challenges and future directions in this emerging field will also be discussed. It is anticipated that interface tissue engineering will lead to the design of a new generation of integrative fixation devices for soft tissue repair, and it will be instrumental for the development of integrated musculoskeletal tissue systems with biomimetic complexity and functionality.
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DOI：
10.1002/jbm.820291107
发表时间：
1995-11-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
DUNN, MG;LIESCH, JB;ZAWADSKY, JP
通讯作者：
ZAWADSKY, JP
影响因子：
14
作者：
Bashur, Chris A.;Dahlgren, Linda A.;Goldstein, Aaron S.
通讯作者：
Goldstein, Aaron S.
DOI：
10.2106/00004623-200209000-00001
发表时间：
2002-09-01
影响因子：
5.3
作者：
Beynnon, BD;Johnson, RJ;Renstrom, P
通讯作者：
Renstrom, P
DOI：
10.1073/pnas.0608837104
发表时间：
2007-02-27
影响因子：
11.1
作者：
Cooper, James A., Jr.;Sahota, Janmeet S.;Laurencin, Cato T.
通讯作者：
Laurencin, Cato T.
影响因子：
14
作者：
Baker, Brendon M.;Mauck, Robert L.
通讯作者：
Mauck, Robert L.