On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin.
On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin.
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DOI：
10.3390/md8051650
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发表时间：
2010-05-10
期刊：
影响因子：
5.4
通讯作者：
Neilan B
中科院分区：
文献类型：
--
作者：
Pearson L;Mihali T;Moffitt M;Kellmann R;Neilan B
通常被称为蓝藻或“蓝绿藻”，由一组不同的氧气光合细菌组成，它们栖息在广泛的水生和陆地环境中，并表现出令人难以置信的形态多样性。许多水生的、形成水华的蓝藻物种能够产生生物活性的次生代谢物，这对人类和其他动物是剧毒的。从毒理学的观点来看，蓝藻毒素分为四大类：神经毒素、肝毒素、细胞毒素和皮肤毒素（刺激性毒素）。然而，它们在结构上是相当多样化的。在过去的十年里，四种主要的蓝藻毒素：微囊藻毒素、结节藻毒素、蛤蚌毒素和柱精子蛋白的生物合成途径已经被遗传学和生化研究阐明。本文综述了这些生物合成途径，并对这些重要的次生代谢产物的化学和毒理学进行了总结。
The cyanobacteria or “blue-green algae”, as they are commonly termed, comprise a diverse group of oxygenic photosynthetic bacteria that inhabit a wide range of aquatic and terrestrial environments, and display incredible morphological diversity. Many aquatic, bloom-forming species of cyanobacteria are capable of producing biologically active secondary metabolites, which are highly toxic to humans and other animals. From a toxicological viewpoint, the cyanotoxins span four major classes: the neurotoxins, hepatotoxins, cytotoxins, and dermatoxins (irritant toxins). However, structurally they are quite diverse. Over the past decade, the biosynthesis pathways of the four major cyanotoxins: microcystin, nodularin, saxitoxin and cylindrospermopsin, have been genetically and biochemically elucidated. This review provides an overview of these biosynthesis pathways and additionally summarizes the chemistry and toxicology of these remarkable secondary metabolites.
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影响因子：
3.2
作者：
Christiansen, G;Fastner, J;Dittmann, E
通讯作者：
Dittmann, E
影响因子：
4.4
作者：
Carmichael, WW;Evans, WR;Moczydlowski, E
通讯作者：
Moczydlowski, E
影响因子：
1.8
作者：
DESILVA, ED;WILLIAMS, DE;ALLEN, TM
通讯作者：
ALLEN, TM
影响因子：
3
作者：
CARMICHAEL, WW
通讯作者：
CARMICHAEL, WW
影响因子：
4.4
作者：
CARMICHAEL, WW;ESCHEDOR, JT;MOORE, RE
通讯作者：
MOORE, RE