Pan-Cancer Analysis of Prognostic and Immune Infiltrates for CXCs.
Pan-Cancer Analysis of Prognostic and Immune Infiltrates for CXCs.
复制标题
CXC 的预后和免疫浸润的全癌症分析
DOI：
10.3390/cancers13164153
复制
发表时间：
2021-08-18
期刊：
影响因子：
5.2
通讯作者：
Wang D
中科院分区：
文献类型：
--
作者：
Li L;Yao W;Yan S;Dong X;Lv Z;Jing Q;Wang Q;Ma B;Hao C;Xue D;Wang D
简单概述CXCs是调节炎症和肿瘤转移的重要基因。虽然有许多研究集中在单个CXC上，但很少有研究提供对整个CXC家族的泛癌分析。我们的结果表明，CXCs是一种潜在的肿瘤治疗靶点，也是一种潜在的预后标记物，可以提高癌症患者的生存率和预后的准确性。同时，我们发现CXCs可能参与了肠道菌群引起的疾病。摘要背景：CXCs是调节炎症和肿瘤转移的重要基因。然而，CXCs在肿瘤中的表达水平、预后价值和免疫浸润尚不清楚。方法：利用多个在线数据集对CXCs的表达、预后和免疫调节进行分析。利用AMADIS数据库和GEO数据库的网络分析，分析肠道菌群对CXCs表达的调控。一个小鼠模型被用来验证肠道细菌失调可以影响CXCs表达的事实。结果：多组资料证实，CXCL3、CXCL3、CXCL8、CXCL9、CXCL10、CXCL14、CXCL17在三种肿瘤中的表达差异显著，CXCL3、CXCL8、CXCL9、CXCL14、CXCL17的表达水平与三种肿瘤的预后显著相关。在三种肿瘤中，CXCs与6种免疫浸润性细胞相关。临床标本免疫组织化学检测证实，CXCL8和CXCL10在三种癌组织中均有较高表达。动物实验表明，肠道菌群失调会影响CXCL8和10的表达。结论：我们的结果进一步阐明了CXCs在癌症中的作用，为乳腺癌、结肠癌和胰腺癌的预后和免疫浸润提供了新的见解，并提示肠道菌群可能通过CXCs影响疾病的进展。
Simple Summary CXCs are important genes that regulate inflammation and tumor metastasis. While there are many studies with a focus on individual CXCs, few present a pan-cancer analysis of the whole CXC family. Our results indicate that CXCs are a potential therapeutic target in a variety of tumors and a potential prognostic marker that could improve the survival of cancer patients and the accuracy of prognosis. Meanwhile, we found that CXCs may be involved in diseases caused by intestinal flora. Abstract Background: CXCs are important genes that regulate inflammation and tumor metastasis. However, the expression level, prognosis value, and immune infiltration of CXCs in cancers are not clear. Methods: Multiple online datasets were used to analyze the expression, prognosis, and immune regulation of CXCs in this study. Network analysis of the Amadis database and GEO dataset was used to analyze the regulation of intestinal flora on the expression of CXCs. A mouse model was used to verify the fact that intestinal bacterial dysregulation can affect the expression of CXCs. Results: In the three cancers, multiple datasets verified the fact that the mRNA expression of this family was significantly different; the mRNA levels of CXCL3, 8, 9, 10, 14, and 17 were significantly correlated with the prognosis of three cancers. CXCs were correlated with six types of immuno-infiltrating cells in three cancers. Immunohistochemistry of clinical samples confirmed that the expression of CXCL8 and 10 was higher in three cancer tissues. Animal experiments have shown that intestinal flora dysregulation can affect CXCL8 and 10 expressions. Conclusion: Our results further elucidate the function of CXCs in cancers and provide new insights into the prognosis and immune infiltration of breast, colon, and pancreatic cancers, and they suggest that intestinal flora may influence disease progression through CXCs.
登录
查看更多内容
TISCH：一个全面的网络资源，可实现肿瘤微环境的交互式单细胞转录组可视化
影响因子：
14.9
作者：
Sun D;Wang J;Han Y;Dong X;Ge J;Zheng R;Shi X;Wang B;Li Z;Ren P;Sun L;Yan Y;Zhang P;Zhang F;Li T;Wang C
通讯作者：
Wang C
影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
GEPIA：用于癌症和正常基因表达谱和交互式分析的网络服务器。
影响因子：
14.9
作者：
Tang Z;Li C;Kang B;Gao G;Li C;Zhang Z
通讯作者：
Zhang Z
影响因子：
3.6
作者：
Lee, Nien-Hung;Nikfarjam, Mehrdad;He, Hong
通讯作者：
He, Hong
影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel