Caffeine alters proliferation of neuronal precursors in the adult hippocampus.
Caffeine alters proliferation of neuronal precursors in the adult hippocampus.
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DOI：
10.1016/j.neuropharm.2009.02.002
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发表时间：
2009-05
影响因子：
4.7
通讯作者：
Magavi SS
中科院分区：
文献类型：
--
作者：
Wentz CT;Magavi SS
哺乳动物的海马体和嗅球中的神经发生持续到成年期。成人的神经发生与学习和记忆有关，并与抑郁症有关。海马区神经发生增加是对一系列刺激的反应，包括暴露在丰富的环境中，增加运动活动，以及服用抗抑郁药物。成年人的神经发生因衰老、压力和睡眠不足而受到抑制。有趣的是，咖啡因以剂量依赖的方式调节许多相同的刺激。我们研究了咖啡因对成年小鼠新生海马神经元的增殖、分化和存活的剂量和时间依赖效应。延长7天的咖啡因注射，以剂量依赖的方式改变小鼠成年海马区前体细胞的增殖；中到高剂量(20-30 mg/kg/天)咖啡因抑制增殖，而超生理剂量(60 mg/kg/天)增加神经元前体细胞的增殖。急性给药1天对细胞增殖无影响。咖啡因的使用不影响神经元分化的早期或晚期标志物的表达，也不影响长期存活率。然而，超生理水平的咖啡因诱导的神经元存活率低于对照细胞；增加增殖并不会增加长期神经发生。这些结果表明，生理剂量的咖啡因可以显著抑制成年海马神经发生。
Neurogenesis continues through adulthood in the hippocampus and olfactory bulb of mammals. Adult neurogenesis has been implicated in learning and memory, and linked with depression. Hippocampal neurogenesis is increased in response to a number of stimuli, including exposure to an enriched environment, increased locomotor activity, and administration of antidepressants. Adult neurogenesis is depressed in response to aging, stress and sleep deprivation. Intriguingly, caffeine modulates a number of these same stimuli in a dose-dependent manner. We examined the dose and duration dependent effects of caffeine on the proliferation, differentiation, and survival of newly generated hippocampal neurons in adult mice. Extended, 7-day caffeine administration, alters the proliferation of adult hippocampal precursors in the mouse in a dose dependent manner; moderate to high doses (20–30mg/kg/day) of caffeine depress proliferation while supraphysiological doses (60mg/kg/day) increase proliferation of neuronal precursors. Acute, 1-day administration had no affect on proliferation. Caffeine administration does not affect the expression of early or late markers of neuronal differentiation, or rates of long-term survival. However, neurons induced in response to supraphysiological levels of caffeine have a lower survival rate than control cells; increased proliferation does not yield an increase in long-term neurogenesis. These results demonstrate that physiologically relevant doses of caffeine can significantly depress adult hippocampal neurogenesis.
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影响因子：
82.9
作者：
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通讯作者：
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DOI：
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发表时间：
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发表时间：
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影响因子：
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通讯作者：
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