Serum glycated albumin is inversely influenced by fat mass and visceral adipose tissue in Chinese with normal glucose tolerance.
Serum glycated albumin is inversely influenced by fat mass and visceral adipose tissue in Chinese with normal glucose tolerance.
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DOI：
10.1371/journal.pone.0051098
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Wang F;Ma X;Hao Y;Yang R;Ni J;Xiao Y;Tang J;Bao Y;Jia W
最近的研究表明，体重指数(BMI)对血清糖化白蛋白(GA)的影响相反，这可能导致对GA监测的短期高血糖控制的低估。本研究旨在探讨人体测量变量(BMI和腰围(W))和准确的肥胖变量(体脂百分比、脂肪质量、游离脂肪质量(FFM)、皮下脂肪面积(SFA)和内脏脂肪面积(VFA))与血清GA的关系。共有2563名糖耐量正常的受试者(1037名男性，593名绝经前女性和933名绝经后女性)接受了生物电阻抗体脂含量测量和磁共振成像。用酶法检测血清GA和GA(Aga)的绝对值。与体重指数25.0 kg/m2组相比，体重指数≥25.0 kg/m2组的空腹血糖、糖化血红蛋白A1c和体脂参数(W、%脂肪、脂肪质量、脂肪比例、游离脂肪酸和挥发性脂肪酸)均显著高于体重指数和体重指数组(P均<0.05)，而糖化血红蛋白和糖化血红蛋白显著低于体重指数和绝经分层组(均P<0.05)。三组GA均随脂肪量的增加而降低(趋势P均<0.001)。在相同的体重指数类别中，肥胖百分比升高的男性和绝经后女性(男性，≥为25%；女性，≥为35%)的GA仍显著低于肥胖正常者(男性，25%；女性，35%)(均P<；0.05)。多元逐步回归分析显示，脂肪百分比、脂肪质量和VFA与GA独立相关。在糖耐量正常的中国人中，血清GA受脂肪量和内脏脂肪组织的影响相反。
Recent studies have revealed that body mass index (BMI) inversely influenced serum glycated albumin (GA), which may cause an underestimation of GA-monitored short-term hyperglycemic control. This study was to investigate the association between anthropometric variables (BMI and waist circumference (W)) and accurate adiposity variables (percentage of body fat (%fat), fat mass, free fat mass (FFM), subcutaneous fat area (SFA), and visceral fat area (VFA)) with serum GA. A total of 2563 subjects (1037 men, 593 premenopausal women, and 933 postmenopausal women) with normal glucose tolerance underwent bioelectrical impedance body fat content measurement and magnetic resonance imaging. Serum GA and absolute value of GA (aGA) were measured by enzymatic assay. Compared to the BMI <25.0 kg/m2 group, the BMI ≥25.0 kg/m2 group had significantly higher fasting plasma glucose, glycated hemoglobin A1c, and body fat parameters including W, %fat, fat mass, FFM, SFA, and VFA, but significantly lower aGA, and GA in all the three sex- and menopause-stratified groups (all P<0.05). GA decreased with the increment of fat mass for all three groups (all P for trend <0.001). In the same BMI category, men and postmenopausal women with elevated %fat (men, ≥25%; women, ≥35%) still had significantly lower GA than those with normal %fat (men, <25%; women, <35%) (all P<0.05). Multiple stepwise regression showed that %fat, fat mass, and VFA were independently associated with GA. Serum GA was inversely influenced by fat mass and visceral adipose tissue in Chinese with normal glucose tolerance.
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影响因子：
8.2
作者：
Furusyo, N.;Koga, T.;Hayashi, J.
通讯作者：
Hayashi, J.
影响因子：
0.7
作者：
Chujo, Keiko;Shima, Kenji;Kawashima, Syu
通讯作者：
Kawashima, Syu
影响因子：
3.8
作者：
Lee, Eun Young;Lee, Byung-Wan;Lee, Hyun Chul
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Lee, Hyun Chul
影响因子：
4
作者：
Fu, X.;Ma, X.;Zhu, S.
通讯作者：
Zhu, S.
影响因子：
9.8
作者：
Kim, Kijin;Valentine, Rudy J.;Gong, Kyungmin
通讯作者：
Gong, Kyungmin