Relationship Between Neutrophil-To-Lymphocyte Ratio and Brain Metastasis in Non-Small Cell Lung Cancer Patients.
Relationship Between Neutrophil-To-Lymphocyte Ratio and Brain Metastasis in Non-Small Cell Lung Cancer Patients.
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DOI：
10.1177/10732748221076805
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Hu D
中科院分区：
文献类型：
--
作者：
Hu C;Wu J;Liu Y;Zhou J;Wang W;Wang X;Guo J;Wang Q;Zhang X;Li D;Xie J;Ding X;Xing Y;Hu D
To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) of patients with non-small cell lung cancer (NSCLC) and their risk of developing brain metastases after adjusting for confounding factors. A retrospective observational study of the general data of patients with NSCLC diagnosed from January 2016 to December 2020. Multivariate logistic regression was used to calculate the dominance ratio (OR) with 95% confidence interval (CI) for NLR and NSCLC brain metastases with subgroup analysis. Generalized summation models and smoothed curve fitting were used to identify whether there was a nonlinear relationship between them. In all 3 models, NLR levels were positively correlated with NSCLC brain metastasis (model 1: OR: 1.12, 95% CI: 1.01-1.23, P = .025; model 2: OR: 1.16, 95% CI: 1.04-1.29, P = .007; model 3: OR: 1.20, 95% CI: 1.05-1.37, P = .006). Stratified analysis showed that this positive correlation was present in patients with adenocarcinoma (LUAD) and female patients (LUAD: OR: 1.30, 95% CI: 1.10-1.54, P = .002; female: OR: 1.52, 95% CI: 1.05-2.20, P = .026), while there was no significant correlation in patients with squamous carcinoma (LUSC) and male patients (LUSC: OR:0.76,95% CI:0.38- 1.53, P = .443; male: OR:1.13, 95% CI:0.95-1.33, P = .159). This study showed that elevated levels of NLR were independently associated with an increased risk of developing brain metastases in patients with NSCLC, and that this correlation varied by TYPE and SEX, with a significant correlation in female patients and patients with LUAD.
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影响因子：
--
作者：
Ha H;Nam AR;Bang JH;Park JE;Kim TY;Lee KH;Han SW;Im SA;Kim TY;Bang YJ;Oh DY
通讯作者：
Oh DY
影响因子：
5.2
作者：
Lorger M
通讯作者：
Lorger M
DOI：
10.1038/nri2888
发表时间：
2011-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.3
作者：
Li, Aijie;Mu, Xiangkui;Yu, Jinming
通讯作者：
Yu, Jinming
影响因子：
5.7
作者：
Bade, Brett C.;Dela Cruz, Charles S.
通讯作者：
Dela Cruz, Charles S.