Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study.
Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study.
复制标题
DOI：
10.1016/j.envres.2008.07.014
复制
发表时间：
2008-10
影响因子：
8.3
通讯作者：
Longnecker, Matthew P.
中科院分区：
文献类型：
--
作者：
Ye, Xibiao;Pierik, Frank H.;Hauser, Russ;Duty, Susan;Angerer, Juergen;Park, Melissa M.;Burdorf, Alex;Hofman, Albert;Jaddoe, Vincent W. V.;Mackenbach, Johan P.;Steegers, Eric A. P.;Tiemeier, Henning;Longnecker, Matthew P.
关键词：
人们越来越关注普通人群中低水平接触有机磷（OP）农药、双酚A（BPA）和邻苯二甲酸酯对健康的潜在影响。我们测量了来自荷兰R代研究的100名孕妇尿样中OP农药的六种二烷基磷酸盐（DAP）代谢物、毒死蜱特异性代谢物（3，5，6-三氯-2-吡啶酚，TCPy）、BPA和十四种邻苯二甲酸酯代谢物的水平。报告了未经调整和肌酐调整的浓度，并与国家健康和营养检查调查和其他研究进行了比较。一般来说，这些代谢物在R世代研究的女性尿液中可检测到，与其他组相比，她们对OP农药和几种邻苯二甲酸酯的暴露水平相对较高，但对BPA的暴露水平相似。总二甲基（DM）代谢物的中位浓度为264.0 nmol/g肌酐（Cr），总DAP的中位浓度为316.0 nmol/g Cr。邻苯二甲酸单乙酯（MEP）的中位浓度为222.0 µg/g Cr;邻苯二甲酸单异丁酯（MiBP）和邻苯二甲酸单正丁酯（MnBP）的中位浓度高于50 µg/g Cr。邻苯二甲酸二（2-乙基己基）酯（DEHP）的三种次级代谢产物的中位浓度均大于20 µg/g Cr。数据表明，R代研究人群提供了广泛的选定环境暴露分布。需要调查含量相对较高的原因和可能的健康影响。
Concern about potential health impacts of low level exposures to organophosphorus (OP) pesticides, bisphenol A (BPA), and phthalates among the general population is increasing. We measured levels of six dialkyl phosphate (DAP) metabolites of OP pesticides, a chlorpyrifos-specific metabolite (3,5,6-trichloro-2-pyridinol, TCPy), BPA, and fourteen phthalate metabolites in urine samples of 100 pregnant women from the Generation R study, the Netherlands. The unadjusted and creatinine-adjusted concentrations were reported, and compared to National Health and Nutrition Examination Survey and other studies. In general, these metabolites were detectable in the urine of the women from the Generation R study and compared with other groups, they had relatively high level exposures to OP pesticides and several phthalates but similar exposure to BPA. The median concentrations of total dimethyl (DM) metabolites was 264.0 nmol/g creatinine (Cr) and of total DAP was 316.0 nmol/g Cr. The median concentration of mono-ethyl phthalate (MEP) was 222.0 µg/g Cr; the median concentrations of mono-isobutyl phthalate (MiBP) and mono-n-butyl phthalate (MnBP) were above 50 µg/g Cr. The median concentrations of the three secondary metabolites of di-2-ethylhexyl phthalate (DEHP) were greater than 20 µg/g Cr. The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation.
登录
查看更多内容
在多种族的城市队列中，怀孕期间室内农药接触。
影响因子：
10.4
作者：
Berkowitz, Gertrud S;Obel, Josephine;Deych, Elena;Lapinski, Robert;Godbold, James;Liu, Zhisong;Landrigan, Philip J;Wolff, Mary S
通讯作者：
Wolff, Mary S
年轻墨西哥裔美国儿童的有机磷酸农药暴露和神经发育。
影响因子：
10.4
作者：
Eskenazi, Brenda;Marks, Amy R.;Bradman, Asa;Harley, Kim;Barr, Dana B.;Johnson, Caroline;Morga, Norma;Jewell, Nicholas A.
通讯作者：
Jewell, Nicholas A.
影响因子：
13.6
作者：
Jaddoe, Vincent W. V.;Mackenbach, Johan P.;Hofman, Albert
通讯作者：
Hofman, Albert
影响因子：
3.4
作者：
Duggan, A;Charnley, G;Yarborough, C
通讯作者：
Yarborough, C
DOI：
10.1016/s1570-0232(02)00785-7
发表时间：
2003-01-25
影响因子：
3
作者：
Koch, HM;Gonzalez-Reche, LM;Angerer, J
通讯作者：
Angerer, J