Auditory dysfunction associated with solvent exposure.
Auditory dysfunction associated with solvent exposure.
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DOI：
10.1186/1471-2458-13-39
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发表时间：
2013-01-16
影响因子：
4.5
通讯作者：
Hickson L
中科院分区：
文献类型：
--
作者：
Fuente A;McPherson B;Hickson L
许多研究表明，溶剂可能导致听觉功能障碍。然而，关于溶剂性听力损失（SIHL）的主要体征和症状仍然知之甚少。本研究的目的是探讨溶剂暴露与外周和中枢听觉功能不良影响之间的关系。选择72名接触溶剂的工人和72名未接触溶剂的工人参加研究。测试单元包括纯音测听（PTA）、瞬态诱发耳声发射（TEOAE）、随机间隙检测（RGD）和噪声听力测试（HINT）。溶剂暴露受试者的平均测试结果比未暴露受试者差。进行了双变量和多变量线性回归模型分析。每个听觉结果（PTA、TEOAE、RGD和HINT）分别独立构建一个模型。对于所有的模型，溶剂暴露与听觉结果显著相关。年龄似乎也与一些听觉结果显著相关。本研究进一步证明了溶剂对外周和中枢听觉功能可能产生的不利影响。讨论了这些影响和选择听力测试来评估SIHL的效用。
A number of studies have demonstrated that solvents may induce auditory dysfunction. However, there is still little knowledge regarding the main signs and symptoms of solvent-induced hearing loss (SIHL). The aim of this research was to investigate the association between solvent exposure and adverse effects on peripheral and central auditory functioning with a comprehensive audiological test battery. Seventy-two solvent-exposed workers and 72 non-exposed workers were selected to participate in the study. The test battery comprised pure-tone audiometry (PTA), transient evoked otoacoustic emissions (TEOAE), Random Gap Detection (RGD) and Hearing-in-Noise test (HINT). Solvent-exposed subjects presented with poorer mean test results than non-exposed subjects. A bivariate and multivariate linear regression model analysis was performed. One model for each auditory outcome (PTA, TEOAE, RGD and HINT) was independently constructed. For all of the models solvent exposure was significantly associated with the auditory outcome. Age also appeared significantly associated with some auditory outcomes. This study provides further evidence of the possible adverse effect of solvents on the peripheral and central auditory functioning. A discussion of these effects and the utility of selected hearing tests to assess SIHL is addressed.
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DOI：
10.1097/00043764-200209000-00002
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影响因子：
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