Childhood-onset depression and arterial stiffness in young adulthood.
Childhood-onset depression and arterial stiffness in young adulthood.
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儿童期起病的抑郁症和青壮年的动脉僵硬。
DOI：
10.1016/j.jpsychores.2021.110551
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发表时间：
2021-09
影响因子：
4.7
通讯作者：
Kovacs M
中科院分区：
文献类型：
--
作者：
Barinas-Mitchell E;Yang X;Matthews KA;Columbus ML;George CJ;Dósa E;Kiss E;Kapornai K;Evans R;Kovacs M
关于儿童期起病的抑郁症和未来血管功能受损的文献是提示性的，但有限。这项研究的目的是确定动脉僵硬是否与儿童期起病的抑郁症有关，动脉僵硬是未来心血管疾病(CVD)的预测指标，在青年时期测量。心脏代谢危险因素和脉搏波速度(PWV)是对有儿童期抑郁症病史(临床诊断为主要抑郁症发作或恶劣心境障碍；N=294名先证者；最初通过匈牙利各地的儿童心理健康机构招募；首次抑郁发作的平均年龄=10.4岁)、他们从未抑郁的完全生物学兄弟姐妹(N=269)和从未抑郁的对照组(N=169)的年轻人进行横断面评估。在PWV就诊时，先证者、兄弟姐妹和对照组的平均年龄分别为25.6岁、25.0岁和21.7岁，8.8%的先证者目前处于抑郁状态。在控制了年龄、性别、年龄、性别、教育程度和家庭聚集性后，PWV(m/S)在不同组之间没有统计学差异(先证者=7.01；兄弟姐妹=6.98；对照组=6.81)。然而，在调整了关键协变量后，在心血管疾病危险因素方面存在着几个跨组差异：与对照组相比，先证者和兄弟姐妹的舒张压更高，高密度脂蛋白胆固醇更低，先证者的甘油三酯更高，兄弟姐妹的体重指数更高(均P<；0.05)。我们发现，儿童时期起病的抑郁症病史与成年后动脉僵硬之间存在关联的证据有限。然而，我们对儿童期起病抑郁症患者心血管危险因素升高的研究结果表明，儿童抑郁症可能易于在以后的生活中增加心血管疾病风险，值得进一步研究。
The literature on childhood-onset depression and future compromised vascular function is suggestive but limited. The objective of this study was to determine if arterial stiffness, a predictor of future cardiovascular disease (CVD), measured in young adulthood, is associated with childhood-onset depression. Cardiometabolic risk factors and pulse wave velocity (PWV), a measure of arterial stiffness, were cross-sectionally assessed in young adults with a history of childhood-onset depression (clinical diagnosis of major depressive episode or dysthymic disorder; N=294 probands; initially recruited via child mental health facilities across Hungary; mean age of first depressive episode=10.4 years), their never-depressed full biological siblings (N=269), and never-depressed controls (N=169). The mean ages of probands, siblings, and controls at the PWV visit were 25.6, 25.0, and 21.7 years, respectively, and 8.8% of the probands were in a current depressive episode. Controlling for age, sex, age*sex, education, and family clusters, PWV (m/s) did not statistically differ across the groups (probands=7.01; siblings=6.98; controls=6.81). However, after adjusting for key covariates, there were several across-group differences in CVD risk factors: compared to controls, probands and siblings had higher diastolic blood pressure and lower high-density lipoprotein cholesterol, probands had higher triglycerides, and siblings had higher body mass index (all p<0.05). We found limited evidence of an association between a history of childhood-onset depression and young adulthood arterial stiffness. However, our findings of elevated cardiovascular risk factors in those with childhood-onset depression suggest that pediatric depression may predispose to increased CVD risk later in life and warrants further investigation.
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影响因子：
37.8
作者：
Gidding SS;Rana JS;Prendergast C;McGill H;Carr JJ;Liu K;Colangelo LA;Loria CM;Lima J;Terry JG;Reis JP;McMahan CA
通讯作者：
McMahan CA
DOI：
10.1016/j.jpeds.2018.03.059
发表时间：
2018-08
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Gross AC;Kaizer AM;Ryder JR;Fox CK;Rudser KD;Dengel DR;Kelly AS
通讯作者：
Kelly AS
影响因子：
2.8
作者：
McMahan, C. Alex;Gidding, Samuel S.;Raitakari, Olli T.
通讯作者：
Raitakari, Olli T.
影响因子：
10.5
作者：
Mannie, Zola N.;Williams, Clare;Cowen, Philip J.
通讯作者：
Cowen, Philip J.
影响因子：
39.3
作者：
Reference Values for Arterial Stiffness' Collaboration
通讯作者：
Reference Values for Arterial Stiffness' Collaboration