Adolescent metabolic syndrome and its components associations with incidence of type 2 diabetes in early adulthood: Tehran lipid and glucose study.
Adolescent metabolic syndrome and its components associations with incidence of type 2 diabetes in early adulthood: Tehran lipid and glucose study.
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青少年代谢综合征及其组分与成年早期2型糖尿病发病率的相关性：德黑兰血脂和血糖研究
DOI：
10.1186/s13098-020-00608-1
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发表时间：
2021-01-02
影响因子：
4.8
通讯作者：
Hadaegh F
中科院分区：
文献类型：
--
作者：
Asghari G;Hasheminia M;Heidari A;Mirmiran P;Guity K;Shahrzad MK;Azizi F;Hadaegh F
探讨青年代谢综合征（MetS）及其组分与成年早期2型糖尿病（T2 DM）的相关性。共有2798名11-19岁的青少年入组研究。在基线时，定义MetS及其组分，包括血压（BP）、腰围（WC）、甘油三酯（TG）、空腹血糖和低HDL-C，以及MetS组分的不同组合。平均随访11.3年后，确定T2 DM。数据分析采用多变量考克斯比例风险回归分析，调整了年龄、性别、T2 DM家族史和成人BMI。报告了风险比（HR）和95%置信区间（CI）。在随访期间，发生了44例T2 DM事件。在不同的个体组分中，只有高WC [HR = 2.63，95%CI（1.39-4.97）]和高TG [HR = 1.82，95%CI（1.00-3.34）]仅在年龄和性别校正模型中仍是显著的预测因子。关于MetS组分的组合，“高TG和高WC”[HR = 2.70，95% CI（1.27-5.77）]，“高血压和高WC”[HR = 2.52，95% CI（1.00-6.33）]、“高TG和高BP”[HR = 2.27，95%CI（1.02-5.05）]以及MetS本身[HR = 2.82，95%CI（1.41-5.64）]与多变量校正模型中的T2 DM事件具有显著相关性。在不同的混杂因素中，在不同的MetS组分组合中，女性和有T2 DM家族史始终与T2 DM的高风险相关。青春期代谢综合征和代谢综合征组分的某些组合可预测成年早期T2 DM。因此，青少年，特别是女性，与MetS成分的组合，以及那些有家族史的T2 DM可以针对生活方式干预。
To investigate the association of youth metabolic syndrome (MetS) and its components, individually and in combination with early adulthood incident type 2 diabetes (T2DM). A total of 2798 adolescents aged 11–19 years enrolled in the study. At baseline, MetS, its components including blood pressure (BP), waist circumference (WC), triglycerides (TGs), fasting plasma glucose, and low HDL-C, and different combinations of MetS components were defined. After a mean 11.3 years of follow-up, T2DM was determined. Multivariable Cox proportional hazard regression analysis adjusted for age, sex, family history of T2DM, and adult BMI was used for data analysis. The hazard ratio (HR) and 95% confidence interval (CI) were reported. During the follow-up, 44 incidents T2DM were developed. Among different individual components, only high WC [HR = 2.63, 95% CI (1.39–4.97)] and high TGs [HR = 1.82, 95% CI (1.00–3.34)] remained as significant predictors only in the age and sex adjusted model. Regarding combinations of MetS components, ‘high TGs and high WC’ [HR = 2.70, 95% CI (1.27–5.77)], ‘high BP and high WC’ [HR = 2.52, 95% CI (1.00–6.33)], ‘high TGs and high BP’ [HR = 2.27, 95% CI (1.02–5.05)] as well as MetS per se [HR = 2.82, 95% CI (1.41–5.64)] had a significant relationship with incident T2DM in the multivariable adjusted model. Among different confounders, being female and having family history of T2DM were consistently associated with higher risk of T2DM, in different combinations of MetS components. Adolescence MetS and some combinations of MetS components predicted early adulthood T2DM. Thus, adolescents, particularly female ones, with combinations of MetS components as well as those with family history of T2DM could be targeted for lifestyle intervention.
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影响因子：
16.2
作者：
Chen, W;Srinivasan, SR;Berenson, GS
通讯作者：
Berenson, GS
影响因子：
5.1
作者：
Morrison, John A.;Friedman, Lisa Aronson;Glueck, Charles J.
通讯作者：
Glueck, Charles J.
影响因子：
5.1
作者：
Cho, N. H.;Shaw, J. E.;Malanda, B.
通讯作者：
Malanda, B.
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
1.1
作者：
Heshmat, Ramin;Hemati, Zeinab;Kelishadi, Roya
通讯作者：
Kelishadi, Roya