Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients.
Acupuncture modulates cortical thickness and functional connectivity in knee osteoarthritis patients.
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针灸调节膝骨关节炎患者的皮质厚度和功能连接。
DOI：
10.1038/srep06482
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发表时间：
2014-09-26
影响因子：
4.6
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Chen X;Spaeth RB;Retzepi K;Ott D;Kong J
在这项研究中，我们调查了皮质厚度和功能连接在纵向针灸治疗膝骨关节炎（OA）患者。在为期四周（六次治疗）的时间内，我们收集了30名患者在第一次，第三次和第六次治疗前的静息状态功能磁共振成像（fMRI）扫描。临床结果显示，与假针灸相比，真针灸的膝关节损伤和骨关节炎结局评分（KOOS）疼痛评分（改善）显著更高。纵向皮质厚度分析显示，与verum组相比，假手术组的左后内侧前额叶皮质（pMPFC）的皮质厚度在治疗期间显著降低。以左侧pMPFC为种子的静息状态功能连接（rsFC）分析显示，经纵向处理后，真针组左侧pMPFC与头端前扣带皮层（rACC）、内侧额极（mFP）和导水管周围灰质（PAG）之间的rsFC显著大于假手术组。我们的研究结果表明，针灸可能通过防止皮质变薄和主要疼痛相关区域的功能连接减少，从而在下行疼痛调节通路中调节疼痛，从而达到治疗膝关节OA疼痛的效果。
In this study, we investigated cortical thickness and functional connectivity across longitudinal acupuncture treatments in patients with knee osteoarthritis (OA). Over a period of four weeks (six treatments), we collected resting state functional magnetic resonance imaging (fMRI) scans from 30 patients before their first, third and sixth treatments. Clinical outcome showed a significantly greater Knee Injury and Osteoarthritis Outcome Score (KOOS) pain score (improvement) with verum acupuncture compared to the sham acupuncture. Longitudinal cortical thickness analysis showed that the cortical thickness at left posterior medial prefrontal cortex (pMPFC) decreased significantly in the sham group across treatment sessions as compared with verum group. Resting state functional connectivity (rsFC) analysis using the left pMPFC as a seed showed that after longitudinal treatments, the rsFC between the left pMPFC and the rostral anterior cingulate cortex (rACC), medial frontal pole (mFP) and periaquiduct grey (PAG) are significantly greater in the verum acupuncture group as compared with the sham group. Our results suggest that acupuncture may achieve its therapeutic effect on knee OA pain by preventing cortical thinning and decreases in functional connectivity in major pain related areas, therefore modulating pain in the descending pain modulatory pathway.
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
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