Evidence that the rat hippocampus has contrasting roles in object recognition memory and object recency memory.
Evidence that the rat hippocampus has contrasting roles in object recognition memory and object recency memory.
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DOI：
10.1037/a0029754
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发表时间：
2012-10
影响因子：
1.9
通讯作者：
Aggleton, John P.
中科院分区：
文献类型：
--
作者：
Albasser, Mathieu M.;Amin, Eman;Lin, Tzu-Ching E.;Iordanova, Mihaela D.;Aggleton, John P.
成年大鼠广泛的，双侧海马神经毒性病变表现出正常的遗忘曲线的对象识别记忆，但受损的密切相关的测试对象近因记忆。目前的研究结果指出，时间顺序信息（近因）的具体机制是依赖于海马体，不涉及对象识别记忆。物体识别测试测量了老鼠同时探索呈现的物体，一个是新的，另一个是熟悉的。任务难度是不同的，通过改变保持延迟后，介绍熟悉的对象，所以创建一个遗忘曲线。海马损伤没有明显的影响，尽管使用的设备（蝴蝶结迷宫），它是可能的，可能会增加刺激干扰的对象列表。相比之下，同样的海马损伤损害了对旧的（不太近的）熟悉物体的正常偏好，而不是对更近的熟悉物体的偏好。隔海马组织的损失和这种损害的近因记忆之间的相关性被发现。在本研究中，识别记忆（备用）和近因记忆（受损）之间的分离是非常引人注目的，因为它可以在同一会话和同一设备中测试相同对象的两种形式的记忆。对象近因缺陷是额外的兴趣，因为它提供了一个例子，非空间记忆缺陷后海马损伤。
Adult rats with extensive, bilateral neurotoxic lesions of the hippocampus showed normal forgetting curves for object recognition memory, yet were impaired on closely related tests of object recency memory. The present findings point to specific mechanisms for temporal order information (recency) that are dependent on the hippocampus and do not involve object recognition memory. The object recognition tests measured rats exploring simultaneously presented objects, one novel and the other familiar. Task difficulty was varied by altering the retention delays after presentation of the familiar object, so creating a forgetting curve. Hippocampal lesions had no apparent effect, despite using an apparatus (bow-tie maze) where it was possible to give lists of objects that might be expected to increase stimulus interference. In contrast, the same hippocampal lesions impaired the normal preference for an older (less recent) familiar object over a more recent, familiar object. A correlation was found between the loss of septal hippocampal tissue and this impairment in recency memory. The dissociation in the present study between recognition memory (spared) and recency memory (impaired) was unusually compelling, because it was possible to test the same objects for both forms of memory within the same session and within the same apparatus. The object recency deficit is of additional interest as it provides an example of a nonspatial memory deficit following hippocampal damage.
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