Spine plasticity in the motor cortex.

Spine plasticity in the motor cortex.
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DOI:
10.1016/j.conb.2010.07.010
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发表时间:
2011-02
影响因子:
5.7
通讯作者:
Zuo Y
Zuo Y
中科院分区:
医学2区
文献类型:
--
作者:
Yu X;Zuo Y

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树突棘是哺乳动物中枢神经系统中大多数兴奋性突触的突触后位点。树突棘的形态和动力学在动物的整个生命周期中都会发生变化,以响应新的经历和神经病理。当动物学习新的任务或经历新的感官刺激时,新的脊椎会迅速形成。随后是选择性地消除先前存在的棘,导致显著的突触重塑。在因损伤或神经系统疾病而受损的大脑中,存活皮层区域的脊髓大量翻转,可能形成新的突触连接,以取代受损区域失去的功能。这些发现表明脊柱可塑性在神经回路的形成和维持中起着重要作用。
Dendritic spines are the postsynaptic sites of the majority of excitatory synapses in the mammalian central nervous system. The morphology and dynamics of dendritic spines change throughout the lifespan of animals, in response to novel experiences and neuropathologies. New spines form rapidly as animals learn new tasks or experience novel sensory stimulations. This is followed by a selective elimination of previously existing spines, leading to significant synaptic remodeling. In the brain damaged by injuries or neurological diseases, spines in surviving cortical regions turn over substantially, potentially forming new synaptic connections to adopt the function lost in the damaged region. These findings suggest that spine plasticity plays important roles in formation and maintenance of a functional neural circuitry.
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