Protective Effect of Natural Antioxidant, Curcumin Nanoparticles, and Zinc Oxide Nanoparticles against Type 2 Diabetes-Promoted Hippocampal Neurotoxicity in Rats.
Protective Effect of Natural Antioxidant, Curcumin Nanoparticles, and Zinc Oxide Nanoparticles against Type 2 Diabetes-Promoted Hippocampal Neurotoxicity in Rats.
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DOI：
10.3390/pharmaceutics13111937
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发表时间：
2021-11-16
期刊：
影响因子：
5.4
通讯作者：
Balbaa M
中科院分区：
文献类型：
--
作者：
Abdulmalek S;Nasef M;Awad D;Balbaa M
大量的流行病学研究结果反复证实了2型糖尿病(T2 DM)与阿尔茨海默病之间的联系。针对大脑中不同的通路进行T2 DM治疗为治疗糖尿病相关的神经元改变提供了一种新颖而有吸引力的策略。因此，我们在这里研究了天然化合物姜黄素纳米颗粒(CurNP)和生物医用金属氧化锌纳米颗粒(ZnONP)缓解T2 DM诱导的大鼠海马区改变的能力。雄性Wistar大鼠喂饲高脂饲料(HFD)8周后，腹腔注射链脲佐菌素(STZ)建立糖尿病模型。模型组给予姜黄素、硫酸锌、两种剂量的姜黄素、硝酸锌、硝酸锌及二甲双胍灌胃治疗6周。HFD/STZ诱导的大鼠除行为障碍外，还表现出许多生化和分子变化。与模型大鼠相比，CurNP和ZnONP可提高学习记忆功能，改善氧化还原和炎症状态，降低Bax，上调bcl2在海马区的表达。此外，MAPK/ERK通路的磷酸化水平显著下调。淀粉样变相关基因的表达和淀粉样β蛋白的积累，以及tau的过度磷酸化，都显著减少。此外，两种纳米颗粒都显著改善了海马区的组织学损害。根据我们的发现，CurNP和ZnONP似乎是潜在的神经保护剂，可以减轻糖尿病并发症相关的海马区毒性。
Numerous epidemiological findings have repeatedly established associations between Type 2 Diabetes Mellitus (T2DM) and Alzheimer’s disease. Targeting different pathways in the brain with T2DM-therapy offers a novel and appealing strategy to treat diabetes-related neuronal alterations. Therefore, here we investigated the capability of a natural compound, curcumin nanoparticle (CurNP), and a biomedical metal, zinc oxide nanoparticle (ZnONP), to alleviate hippocampal modifications in T2DM-induced rats. The diabetes model was induced in male Wistar rats by feeding a high-fat diet (HFD) for eight weeks followed by intraperitoneal injection of streptozotocin (STZ). Then model groups were treated orally with curcumin, zinc sulfate, two doses of CurNP and ZnONP, as well as metformin, for six weeks. HFD/STZ-induced rats exhibited numerous biochemical and molecular changes besides behavioral impairment. Compared with model rats, CurNP and ZnONP boosted learning and memory function, improved redox and inflammation status, lowered Bax, and upregulated Bcl2 expressions in the hippocampus. In addition, the phosphorylation level of the MAPK/ERK pathway was downregulated significantly. The expression of amyloidogenic-related genes and amyloid-beta accumulation, along with tau hyperphosphorylation, were lessened considerably. In addition, both nanoparticles significantly improved histological lesions in the hippocampus. Based on our findings, CurNP and ZnONP appear to be potential neuroprotective agents to mitigate diabetic complications-associated hippocampal toxicity.
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影响因子：
5.8
作者：
ELLMAN, GL;COURTNEY, KD;FEATHERSTONE, RM
通讯作者：
FEATHERSTONE, RM
DOI：
10.3390/molecules26103011
发表时间：
2021-05-18
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
ELBini-Dhouib I;Doghri R;Ellefi A;Degrach I;Srairi-Abid N;Gati A
通讯作者：
Gati A
影响因子：
2.7
作者：
Hamza, Reham Z.;Al-Salmi, Fawziah A.;El-Shenawy, Nahla S.
通讯作者：
El-Shenawy, Nahla S.
影响因子：
4.2
作者：
Devi L;Ohno M
通讯作者：
Ohno M
影响因子：
5.9
作者：
Gammoh NZ;Rink L
通讯作者：
Rink L