Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology.
Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology.
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DOI：
10.1016/j.immuni.2009.09.010
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发表时间：
2009-11-20
期刊：
影响因子：
32.4
通讯作者：
Ransohoff RM
中科院分区：
文献类型：
--
作者：
Ransohoff RM
最近的报告描述了免疫和神经系统常见的几个分子实体。其中最突出的是趋化因子及其受体，它们在免疫生物学和神经生物学中发挥着非常多样化和强有力的作用。这篇综述列举了几个说明性的例子，并介绍了在这两个系统中都存在的趋化因子作用的一般原理：趋化因子倾向于在时空精确定位靶细胞的过程中同等地阻止细胞并使其移动；信号和非信号受体协作调节趋化因子环境以获得最大疗效；循环血细胞和实质细胞上单个趋化因子受体的表达通常用于协调复杂的组织反应。研究人员面临的任务是将关键受体如CXCR4、CXCR2、CX3CR1、CCR2(及其配体和其他多功能趋化因子受体)的作用整合到对病理过程中事件的连贯描述中，以指导治疗开发。
Recent reports describe several molecular entities common to the immune and nervous systems. Salient among them are the chemokines and their receptors, which play remarkably varied and potent roles in immunobiology and neurobioloogy. This review limns several illustrative examples and presents general principles of chemokine action which are manifest in both systems: chemokines tend equally to arrest cells and to make them move, in the process of positioning target cells with spatiotemporal precision;’ signaling and non-signaling receptors collaborate to adjust the chemokine environment for maximal efficacy; expression of a single chemokine receptor on circulating blood cells and parenchymal cells is often used to coordinate complex tissue responses. The task before investigators is to integrate knowledge of the roles of key receptors such as CXCR4, CXCR2, CX3CR1, CCR2 (as well as their ligands and other multifunctional chemokine receptors) into a coherent account of events during pathologic processes, in order to guide therapeutic development.
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影响因子：
5.6
作者：
Chen, Xiao-Ke;Xiong, Ying-Fei;Zhou, Zhuan
通讯作者：
Zhou, Zhuan
DOI：
10.1007/bf01179819
发表时间：
1995-09-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
BELL, MD;PERRY, VH
通讯作者：
PERRY, VH
DOI：
10.1073/pnas.84.20.7188
发表时间：
1987-10-01
影响因子：
11.1
作者：
ANISOWICZ, A;BARDWELL, L;SAGER, R
通讯作者：
SAGER, R
影响因子：
2.8
作者：
Borroni, Elena Monica;Bonecchi, Raffaella;Locati, Massimo
通讯作者：
Locati, Massimo
影响因子：
2.4
作者：
Charo, IF;Peters, W
通讯作者：
Peters, W