Long-term coding of personal and universal associations underlying the memory web in the human brain.
Long-term coding of personal and universal associations underlying the memory web in the human brain.
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DOI：
10.1038/ncomms13408
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发表时间：
2016-11-15
影响因子：
16.6
通讯作者：
Quiroga, Rodrigo Quian
中科院分区：
文献类型：
--
作者：
De Falco, Emanuela;Ison, Matias J.;Fried, Itzhak;Quiroga, Rodrigo Quian
内侧颞叶（MTL）是陈述性记忆的关键区域，它的神经元在联想学习任务中会改变其调谐。然而，目前还不清楚这些神经元表征的持久性如何，以及它们是否超过了任务的执行。为了解决这个问题，我们研究了神经外科患者MTL神经元对已知概念（人和地点）的反应。使用患者提供的关联分数和基于网络的度量，在这里，我们表明，每当MTL神经元对一个以上的概念做出反应时，这些概念通常是相关的。此外，基于神经元的反应模式，可以成功地预测概念之间的关联程度。这些结果为MTL神经元长期参与持久关联的表征提供了证据，这是人类陈述性记忆的标志。当人们学习将物品配对时，内侧颞叶的神经元会改变它们的放电模式，但目前还不清楚这种配对是否持续。在这里，作者发现人类的单个内侧颞叶神经元倾向于对概念上密切相关的项目做出类似的反应。
Neurons in the medial temporal lobe (MTL), a critical area for declarative memory, have been shown to change their tuning in associative learning tasks. Yet, it is unclear how durable these neuronal representations are and if they outlast the execution of the task. To address this issue, we studied the responses of MTL neurons in neurosurgical patients to known concepts (people and places). Using association scores provided by the patients and a web-based metric, here we show that whenever MTL neurons respond to more than one concept, these concepts are typically related. Furthermore, the degree of association between concepts could be successfully predicted based on the neurons' response patterns. These results provide evidence for a long-term involvement of MTL neurons in the representation of durable associations, a hallmark of human declarative memory. Neurons in the medial temporal lobe change their firing patterns as people learn to pair items together, yet it is unclear if this pairing lasts. Here, authors find that single medial temporal lobe neurons in humans tend to respond similarly to items that are closely conceptually related.
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DOI：
10.1016/j.cub.2009.06.060
发表时间：
2009-08-11
期刊：
Current biology : CB
影响因子：
--
作者：
Quian Quiroga R;Kraskov A;Koch C;Fried I
通讯作者：
Fried I
影响因子：
16.6
作者：
Reddy, Leila;Poncet, Marlene;Roelfsema, Pieter R.
通讯作者：
Roelfsema, Pieter R.
影响因子：
16.2
作者：
McKenzie S;Frank AJ;Kinsky NR;Porter B;Rivière PD;Eichenbaum H
通讯作者：
Eichenbaum H
DOI：
10.1073/pnas.0400162101
发表时间：
2004-03-02
影响因子：
11.1
作者：
Hampson, RE;Pons, TP;Deadwyler, SA
通讯作者：
Deadwyler, SA
影响因子：
5.3
作者：
Redish, AD;Battaglia, FP;Barnes, CA
通讯作者：
Barnes, CA