The Role of Diet in the Pathogenesis and Management of Inflammatory Bowel Disease: A Review.
The Role of Diet in the Pathogenesis and Management of Inflammatory Bowel Disease: A Review.
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DOI：
10.3390/nu13010135
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发表时间：
2020-12-31
期刊：
影响因子：
5.9
通讯作者：
Danta M
中科院分区：
文献类型：
--
作者：
Wark G;Samocha-Bonet D;Ghaly S;Danta M
炎症性肠病，包括溃疡性结肠炎和克罗恩病，是胃肠道慢性复发和缓解性炎症性疾病，在全球范围内的患病率和发病率都在增加。它们与发病率高、患者个人生活质量下降有关，并通过直接和间接成本对社会造成越来越大的负担。目前的治疗策略依赖于免疫抑制，虽然有效，但与不良事件有关。流行病学证据表明，饮食影响IBD发病风险并调节疾病活动。使用饮食作为治疗选择对患者和临床医生都有吸引力，因为它的可用性，低成本和副作用少。饮食可能通过几种机制影响IBD风险和疾病行为。首先，饲料中的某些成分会影响微生物群的结构和功能，并对免疫活性产生下游影响。其次，饮食成分会改变粘膜屏障的结构和通透性，最后，饮食成分可能与免疫反应的成分直接相互作用。本文将总结饮食-微生物-免疫系统相互作用的机制，概述饮食与IBD之间关系的关键研究，以及证明饮食对疾病控制影响的证据。最后，本综述将概述目前针对活动性乳糜泻的处方饮食疗法。
Inflammatory bowel diseases, which include ulcerative colitis and Crohn’s disease, are chronic relapsing and remitting inflammatory diseases of the gastrointestinal tract that are increasing in prevalence and incidence globally. They are associated with significant morbidity, reduced quality of life to individual sufferers and are an increasing burden on society through direct and indirect costs. Current treatment strategies rely on immunosuppression, which, while effective, is associated with adverse events. Epidemiological evidence suggests that diet impacts the risk of developing IBD and modulates disease activity. Using diet as a therapeutic option is attractive to patients and clinicians alike due to its availability, low cost and few side effects. Diet may influence IBD risk and disease behaviour through several mechanisms. Firstly, some components of the diet influence microbiota structure and function with downstream effects on immune activity. Secondly, dietary components act to alter the structure and permeability of the mucosal barrier, and lastly dietary elements may have direct interactions with components of the immune response. This review will summarise the mechanisms of diet–microbial–immune system interaction, outline key studies examining associations between diet and IBD and evidence demonstrating the impact of diet on disease control. Finally, this review will outline current prescribed dietary therapies for active CD.
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影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
影响因子：
9.8
作者：
Amre, Devendra K.;D'Souza, Savio;Seidman, Ernest G.
通讯作者：
Seidman, Ernest G.
影响因子：
5.9
作者：
Altobelli E;Del Negro V;Angeletti PM;Latella G
通讯作者：
Latella G
影响因子：
2.8
作者：
Asarat, M.;Vasiljevic, T.;Donkor, O.
通讯作者：
Donkor, O.
DOI：
10.1093/ecco-jcc/jjx136
发表时间：
2018-01-24
期刊：
Journal of Crohn's & colitis
影响因子：
--
作者：
Andersen V;Chan S;Luben R;Khaw KT;Olsen A;Tjonneland A;Kaaks R;Grip O;Bergmann MM;Boeing H;Hultdin J;Karling P;Overvad K;Oldenburg B;Opstelten J;Boutron-Ruault MC;Carbonnel F;Racine A;Key T;Masala G;Palli D;Tumino R;Trichopoulou A;Riboli E;Hart A
通讯作者：
Hart A