Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD).
Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD).
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DOI：
10.1093/ecco-jcc/jjx136
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发表时间：
2018-01-24
期刊：
影响因子：
--
通讯作者：
Hart A
中科院分区：
文献类型：
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作者：
Andersen V;Chan S;Luben R;Khaw KT;Olsen A;Tjonneland A;Kaaks R;Grip O;Bergmann MM;Boeing H;Hultdin J;Karling P;Overvad K;Oldenburg B;Opstelten J;Boutron-Ruault MC;Carbonnel F;Racine A;Key T;Masala G;Palli D;Tumino R;Trichopoulou A;Riboli E;Hart A
目前缺乏调查纤维摄入和炎症性肠病发展的基于人群的前瞻性队列研究。我们的目的是调查大量欧洲人群中纤维摄入量与克罗恩病 [CD] 和溃疡性结肠炎 [UC] 发展之间的关联。 1991 年至 1998 年间，欧洲 8 个国家总共招募了 401326 名 20-80 岁的参与者。在基线时，使用食物频率调查问卷记录纤维摄入量（总纤维、来自水果、蔬菜和谷物的纤维）。监测该队列的炎症性肠病的发展。每个病例与四个对照相匹配，并使用条件逻辑回归计算暴露的比值比 [OR]。根据吸烟状况进行敏感性分析。总共有 104 名参与者和 221 名参与者分别开发了事件 CD 和 UC。对于 CD 和 UC，总纤维或任何单个来源与四分位数或四分位数之间的趋势没有统计学上的显着关联。这些关联并未受到吸烟和能量摄入调整的影响。根据吸烟状况进行的分层显示，除了与非吸烟者中谷物纤维和 CD 呈负相关外，没有发现任何结果 [四分位数 4 与 1 OR = 0.12，95% 置信区间 = 0.02–0.75，p = 0.023，四分位数之间的 OR 趋势 = 0.50，95% 置信区间 = 0.29–0.86，p = 0.017]。结果并不支持膳食纤维与 UC 病因有关的假设，尽管未来的工作应该根据吸烟状况调查特定类型的纤维是否可能对 CD 具有保护作用。
Population-based prospective cohort studies investigating fibre intake and development of inflammatory bowel disease are lacking. Our aim was to investigate the association between fibre intake and the development of Crohn’s disease [CD] and ulcerative colitis [UC] in a large European population. In total, 401326 participants, aged 20–80 years, were recruited in eight countries in Europe between 1991 and 1998. At baseline, fibre intake [total fibres, fibres from fruit, vegetables and cereals] was recorded using food frequency questionnaires. The cohort was monitored for the development of inflammatory bowel disease. Each case was matched with four controls and odds ratios [ORs] for the exposures were calculated using conditional logistic regression. Sensitivity analyses according to smoking status were computed. In total, 104 and 221 participants developed incident CD and UC, respectively. For both CD and UC, there were no statistically significant associations with either quartiles, or trends across quartiles, for total fibre or any of the individual sources. The associations were not affected by adjusting for smoking and energy intake. Stratification according to smoking status showed null findings apart from an inverse association with cereal fibre and CD in non-smokers [Quartile 4 vs 1 OR = 0.12, 95% confidence interval = 0.02–0.75, p = 0.023, OR trend across quartiles = 0.50, 95% confidence interval = 0.29–0.86, p = 0.017]. The results do not support the hypothesis that dietary fibre is involved in the aetiology of UC, although future work should investigate whether there may be a protective effect of specific types of fibre according to smoking status in CD.
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影响因子：
--
作者：
Andersen V;Ernst A;Christensen J;Østergaard M;Jacobsen BA;Tjønneland A;Krarup HB;Vogel U
通讯作者：
Vogel U
影响因子：
29.4
作者：
Costea, Irina;Mack, David R.;Amre, Devendra K.
通讯作者：
Amre, Devendra K.
影响因子：
3.2
作者：
Hart, Andrew R.;Luben, Robert;Bingham, Sheila
通讯作者：
Bingham, Sheila
影响因子：
50.5
作者：
RIBOLI, E
通讯作者：
RIBOLI, E
影响因子：
4.7
作者：
Slimani, N;Ferrari, P;Riboli, E
通讯作者：
Riboli, E