High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
High prevalence of HIV-1 intersubtype B'/C recombinants among injecting drug users in Dehong, China.
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DOI：
10.1371/journal.pone.0065337
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Shang H
中科院分区：
文献类型：
--
作者：
Han X;An M;Zhao B;Duan S;Yang S;Xu J;Zhang M;McGoogan JM;Takebe Y;Shang H
目的了解云南德宏市静脉吸毒人群中HIV-1基因的分布情况。对95名HIV阳性注射吸毒者的血液样本进行了回顾性分析。样本于2005年至2009年期间从云南省西部的德宏州的四个城市采集，德宏州是中国艾滋病疫情的地理发源地。分析HIV-1 Gag、部分Poll、VPR-env片段、半基因组或近全长序列，以确定每个受试者的HIV-1基因类型。结果与德宏和邻国缅甸过去对注射吸毒者的研究结果进行了比较。我们观察到德宏注射吸毒者中B‘/C重组体的高流行率(82.4%)，其结构特征与以前在德宏或缅甸报道的不匹配。此外，HIV-1B‘/C重组型在老年人群(p = 0.034)、龙川地区人群(p = 0.022)和2000年至2004年确诊人群(p = 0.004)中的优势分布在地理和时间分布上存在显著的统计学差异。多种新的B‘/C重组形式的日益流行表明，HIV-1亚型间重组在云南西部是实质性的和正在进行的。这反映了该地区注射吸毒者的高危行为，并表明需要在德宏和中国周围的其他高发地区采取更强有力的监测和预防措施。
To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province. Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005 and 2009 from four cities in Dehong prefecture, western Yunnan province, the geographical origin of the HIV epidemic in China. HIV-1 gag, partial pol, vpr-env fragment, half-genome, or near-full-length sequences were analyzed to determine the HIV-1 genotypes of each subject. Results were compared with findings from past studies of IDUs in Dehong and in neighboring Myanmar. We observed a high prevalence of B′/C recombinants (82.4%) among IDUs in Dehong, the structural profiles of which do not match those previously reported in Dehong or in Myanmar. Furthermore, statistically significant differences in geographical and temporal distributions of HIV-1 genotypes were characterized by a predominance of HIV-1 B′/C recombinant forms among older subjects(p = 0.034), subjects from Longchuan district (p = 0.022), and subjects diagnosed between 2000 and 2004 (p = 0.004). The increasing prevalence of multiple, new B′/C recombinant forms suggest that HIV-1 intersubtype recombination is substantial and ongoing in western Yunnan. This reflects the high-risk behavior of IDUs in this region and argues the need for stronger monitoring and prevention measures in Dehong and other high-prevalence areas around China.
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