Robustness and plasticity in Drosophila heat avoidance.
Robustness and plasticity in Drosophila heat avoidance.
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DOI：
10.1038/s41467-021-22322-w
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发表时间：
2021-04-06
影响因子：
16.6
通讯作者：
Gallio M
中科院分区：
文献类型：
--
作者：
Simões JM;Levy JI;Zaharieva EE;Vinson LT;Zhao P;Alpert MH;Kath WL;Para A;Gallio M
简单的先天行为通常被描述为硬连线和很大程度上不灵活。在这里，我们表明，避免高温，一个简单的先天行为，包含意想不到的可塑性在果蝇。首先，我们证明了热受体神经元的天线和它们的分子热传感器，Gr28B.d，是必不可少的苍蝇产生逃避转身远离热。高分辨率苍蝇跟踪结合热环境的3D模拟显示，在陡峭的热梯度中，逃生转弯的方向由天线之间的微小温差（0.1°-1 °C）决定。同时，活体钙成像证实，这种小刺激可靠地激活外周热敏神经元和中央回路。接下来，根据我们的测量，我们发展了一个飞行/车辆模型与两个对称的传感器和电机（“Braitenberg车辆”），它非常接近基本的苍蝇趋热性。真实的苍蝇和硬连线车辆之间的关键差异表明，苍蝇热回避涉及决策，依赖于快速学习，并对新的条件具有鲁棒性，这些特征通常与更复杂的行为相关。Simonies，Levy等人使用实验和模型相结合的方法来研究果蝇如何避开危险的热量。他们发现，苍蝇利用触角之间的微小温差来避开热危险;他们还证明了热回避，一种简单的先天行为，包含意想不到的可塑性。
Simple innate behavior is often described as hard-wired and largely inflexible. Here, we show that the avoidance of hot temperature, a simple innate behavior, contains unexpected plasticity in Drosophila. First, we demonstrate that hot receptor neurons of the antenna and their molecular heat sensor, Gr28B.d, are essential for flies to produce escape turns away from heat. High-resolution fly tracking combined with a 3D simulation of the thermal environment shows that, in steep thermal gradients, the direction of escape turns is determined by minute temperature differences between the antennae (0.1°–1 °C). In parallel, live calcium imaging confirms that such small stimuli reliably activate both peripheral thermosensory neurons and central circuits. Next, based on our measurements, we evolve a fly/vehicle model with two symmetrical sensors and motors (a “Braitenberg vehicle”) which closely approximates basic fly thermotaxis. Critical differences between real flies and the hard-wired vehicle reveal that fly heat avoidance involves decision-making, relies on rapid learning, and is robust to new conditions, features generally associated with more complex behavior. Simões, Levy et al. use a combination of experiments and models to study how Drosophila flies steer away from dangerous heat. They discover that flies use small temperature differences between the antennae to turn clear of thermal danger; they also demonstrate that heat avoidance, a simple innate behavior, contains unexpected plasticity.
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影响因子：
64.8
作者：
通讯作者：
--
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
64.5
作者：
Jovanic, Tihana;Schneider-Mizell, Casey Martin;Zlatic, Marta
通讯作者：
Zlatic, Marta
影响因子：
5.2
作者：
HUEY, RB;CRILL, WD;WEBER, KE
通讯作者：
WEBER, KE
DOI：
10.1016/j.cub.2009.06.022
发表时间：
2009-08-11
期刊：
Current biology : CB
影响因子：
--
作者：
Duistermars BJ;Chow DM;Frye MA
通讯作者：
Frye MA