Rapidly liver-clearable rare-earth core-shell nanoprobe for dual-modal breast cancer imaging in the second near-infrared window.
Rapidly liver-clearable rare-earth core-shell nanoprobe for dual-modal breast cancer imaging in the second near-infrared window.
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可快速肝脏清除的稀土核壳纳米探针，用于第二近红外窗口中的双模式乳腺癌成像
DOI：
10.1186/s12951-021-01112-y
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发表时间：
2021-11-17
影响因子：
10.2
通讯作者：
Gao M
中科院分区：
文献类型：
--
作者：
Wei Z;Duan G;Huang B;Qiu S;Zhou D;Zeng J;Cui J;Hu C;Wang X;Wen L;Gao M
荧光成像技术具有无创性和上级时间分辨率等优点，在临床前研究中得到了广泛的应用。然而，基于紫外光（UV，200-400 nm）和可见光（维斯，400-650 nm）的传统光学方法受到穿透力低、信噪比和高背景自发荧光干扰的限制。因此，近红外-II（NIR-II 1000-1700 nm）纳米探针的开发吸引了对体内成像的显著关注。遗憾的是，大多数NIR-II荧光探针，特别是无机NP，几乎没有从网状内皮系统（RES）中排出，产生了匿名的长期循环安全性问题。在这里，我们开发了一种简单的策略，用于制造Nd 3+掺杂的稀土核壳纳米颗粒（Nd-RENP），NaGdF 4：5%Nd@NaLuF4，在NIR-II窗口具有强发射。更重要的是，Nd-RENP可以从肝胆途径中快速消除，降低了在RES中长期保留的潜在风险。此外，Nd-RENP成功地用于NIR-II体内成像和磁共振成像（MRI）造影剂，能够精确检测乳腺癌。合理设计的Nd-RENP纳米探针表现出快速清除特性，揭示了对肿瘤病变的无创术前成像和实时术中监测的潜在应用。在线版本包含补充材料，可通过10.1186/s12951-021-01112-y获得。
Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200–400 nm) and visible light (Vis, 400–650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000–1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue. Here, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core–shell nanoparticles (Nd-RENPs), NaGdF4:5%Nd@NaLuF4, with strong emission in the NIR-II window. What’s more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer. The rationally designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision. The online version contains supplementary material available at 10.1186/s12951-021-01112-y.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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