Rare-earth-doped biological composites as in vivo shortwave infrared reporters.
Rare-earth-doped biological composites as in vivo shortwave infrared reporters.
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DOI：
10.1038/ncomms3199
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发表时间：
2013
影响因子：
16.6
通讯作者：
Moghe, P. V.
中科院分区：
文献类型：
--
作者：
Naczynski, D. J.;Tan, M. C.;Zevon, M.;Wall, B.;Kohl, J.;Kulesa, A.;Chen, S.;Roth, C. M.;Riman, R. E.;Moghe, P. V.
用于疾病筛查和图像引导外科手术干预的体内光学成像的扩展需要明亮发射的组织特异性材料，其光学传输通过活组织，并且可以用实时显示数据的便携式系统成像。最近的工作表明，一个新的窗口跨越短波长红外区域可以提高体内成像灵敏度超过近红外光。在这里，我们报告的第一个证据，多光谱，实时短波长红外成像提供解剖分辨率使用明亮的发射稀土纳米材料，并证明其适用于疾病靶向成像。稀土纳米材料与人血清白蛋白的无机蛋白质纳米复合物促进了稀土纳米材料的全身生物分布，导致在肿瘤组织中的积累和保留增加，这通过红外信号强度的局部增强而可视化。我们的研究结果为新一代多功能生物医学纳米材料奠定了基础，这些材料可以基于开创性的红外成像技术推进疾病监测。
The extension of in vivo optical imaging for disease screening and image-guided surgical interventions requires brightly-emitting, tissue-specific materials that optically transmit through living tissue and can be imaged with portable systems that display data in real-time. Recent work suggests that a new window across the short wavelength infrared region can improve in vivo imaging sensitivity over near infrared light. Here we report on the first evidence of multispectral, real-time short wavelength infrared imaging offering anatomical resolution using brightly-emitting rare-earth nanomaterials and demonstrate their applicability toward disease-targeted imaging. Inorganic-protein nanocomposites of rare-earth nanomaterials with human serum albumin facilitated systemic biodistribution of the rare-earth nanomaterials resulting in the increased accumulation and retention in tumor tissue that was visualized by the localized enhancement of infrared signal intensity. Our findings lay the groundwork for a new generation of versatile, biomedical nanomaterials that can advance disease monitoring based on a pioneering infrared imaging technique.
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