Juvenile Selenium Deficiency Impairs Cognition, Sensorimotor Gating, and Energy Homeostasis in Mice.
Juvenile Selenium Deficiency Impairs Cognition, Sensorimotor Gating, and Energy Homeostasis in Mice.
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DOI：
10.3389/fnut.2021.667587
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发表时间：
2021
影响因子：
5
通讯作者：
Pitts MW
中科院分区：
文献类型：
--
作者：
Kilonzo VW;Sasuclark AR;Torres DJ;Coyle C;Pilat JM;Williams CS;Pitts MW
硒（Se）是一种对哺乳动物生命至关重要的必需微量营养素。其生物学效应主要是通过与硒蛋白共翻译掺入介导的，作为独特的氨基酸，硒代半胱氨酸。这些蛋白质在氧化还原信号传导中起重要作用，包括谷胱甘肽过氧化物酶和硫氧还蛋白还原酶。硒的环境分布在世界范围内变化很大，对人类和动物的硒状态产生了相应的影响。硒摄入量在一个狭窄的范围内优化硒依赖性抗氧化酶的活性，而硒缺乏和硒过量都会对健康产生不利影响。硒缺乏影响世界人口的很大一部分，甲状腺功能减退、心肌病、免疫力下降和认知能力受损是常见症状。虽然相对不那么普遍，但硒过量也可能产生有害后果，并与促进人类代谢和神经退行性疾病有关。在此，我们试图全面评估硒缺乏和硒过量对小鼠神经行为和代谢测试电池的发育影响。硒缺乏引起认知缺陷，改变感觉运动门控，增加肥胖，而硒过量是令人惊讶的有益。
Selenium (Se) is an essential micronutrient of critical importance to mammalian life. Its biological effects are primarily mediated via co-translational incorporation into selenoproteins, as the unique amino acid, selenocysteine. These proteins play fundamental roles in redox signaling and includes the glutathione peroxidases and thioredoxin reductases. Environmental distribution of Se varies considerably worldwide, with concomitant effects on Se status in humans and animals. Dietary Se intake within a narrow range optimizes the activity of Se-dependent antioxidant enzymes, whereas both Se-deficiency and Se-excess can adversely impact health. Se-deficiency affects a significant proportion of the world's population, with hypothyroidism, cardiomyopathy, reduced immunity, and impaired cognition being common symptoms. Although relatively less prevalent, Se-excess can also have detrimental consequences and has been implicated in promoting both metabolic and neurodegenerative disease in humans. Herein, we sought to comprehensively assess the developmental effects of both Se-deficiency and Se-excess on a battery of neurobehavioral and metabolic tests in mice. Se-deficiency elicited deficits in cognition, altered sensorimotor gating, and increased adiposity, while Se-excess was surprisingly beneficial.
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影响因子：
4.8
作者：
Burk, Raymond F.;Hill, Kristina E.;Zhang, Wanqi
通讯作者：
Zhang, Wanqi
DOI：
10.1073/pnas.1611576114
发表时间：
2017-03-14
影响因子：
11.1
作者：
Jones GD;Droz B;Greve P;Gottschalk P;Poffet D;McGrath SP;Seneviratne SI;Smith P;Winkel LH
通讯作者：
Winkel LH
影响因子：
5.2
作者：
Hoffmann, Peter R.;Berry, Marla J.
通讯作者：
Berry, Marla J.
中国汉族人群精神分裂症患者与对照者血清微量元素差异
影响因子：
4.6
作者：
Cai L;Chen T;Yang J;Zhou K;Yan X;Chen W;Sun L;Li L;Qin S;Wang P;Yang P;Cui D;Burmeister M;He L;Jia W;Wan C
通讯作者：
Wan C
影响因子：
5.9
作者：
Błażewicz A;Szymańska I;Dolliver W;Suchocki P;Turło J;Makarewicz A;Skórzyńska-Dziduszko K
通讯作者：
Skórzyńska-Dziduszko K